CLEC12A and CLEC1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC12A	CLEC1A
Description		C-type lectin domain family 12 member A	C-type lectin domain family 1 member A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Signaling Receptor Regulator Activity Pattern Recognition Receptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Neutrophil Activation Involved In Immune Response Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response Negative Regulation Of Neutrophil Activation Negative Regulation Of Dendritic Cell Differentiation	Signal Transduction Cell Surface Receptor Signaling Pathway
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061)	Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: CFTR CLEC1A	14 interacting genes: CERS4 CLEC12A FFAR2 FNDC9 GJA8 GPR152 GPX8 LMNA LRRC25 LRRC4C MRPS18B RNF19B STX1A TRAM1L1
Entrez ID		160364	51267
HPRD ID		14719	09489
Ensembl ID		ENSG00000172322	ENSG00000150048
Uniprot IDs		Q5QGZ9	B3KRP6 B4DV89 E7ESV9 E9PFB4 Q8NC01
PDB IDs		8JAH 8W8T 8W9J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Membrane Docking Positive Regulation Of Exocytosis
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