CLEC12A

Description		C-type lectin domain family 12 member A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Signaling Receptor Regulator Activity Pattern Recognition Receptor Activity
	Biological Process	Neutrophil Activation Involved In Immune Response Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response Negative Regulation Of Neutrophil Activation Negative Regulation Of Dendritic Cell Differentiation
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061)
Interacting Genes		2 interacting genes: CFTR CLEC1A
Entrez ID		160364
HPRD ID		14719
Ensembl ID		ENSG00000172322
Uniprot IDs		Q5QGZ9
PDB IDs		8JAH 8W8T 8W9J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Membrane Docking Positive Regulation Of Exocytosis
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