CYP51A1 and GRM3

		CYP51A1	GRM3
Description		cytochrome P450 family 51 subfamily A member 1	glutamate metabotropic receptor 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Postsynaptic Density Membrane Axon Presynaptic Membrane Neuron Projection Dendritic Spine Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	Monooxygenase Activity Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Negative Regulation Of Amyloid-beta Clearance	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Cellular Response To Stress Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Tioconazole Itraconazole Levoketoconazole (S)-econazole	LY2140023
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lifespan ( 25918517) Pulse pressure ( 30578418)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 28991256 25056061) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		3 interacting genes: SHANK3 TMUB1 ZNF420	6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN
Entrez ID		1595	2913
HPRD ID		03381	03070
Ensembl ID		ENSG00000001630	ENSG00000198822
Uniprot IDs		Q16850	A4D1D0 Q14832
PDB IDs		3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ 8SBI 8SS0	3SM9 4XAR 5CNK 5CNM 6B7H 7WI6 7WI8 7WIH 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 9II2 9II3
Enriched GO Terms of Interacting Partners?		Postsynaptic Membrane Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic ERAD Pathway Group II Metabotropic Glutamate Receptor Activity Guanylate Kinase-associated Protein Clustering Oligosaccharyl Transferase Activity Dendritic Spine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Postsynaptic Density Neuron Projection Astrocyte Projection Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Response To Endoplasmic Reticulum Stress Vocal Learning Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity GABAergic Neuron Differentiation Neurotransmitter-gated Ion Channel Clustering Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Postsynaptic Specialization Assembly Oligosaccharyltransferase Complex B Oligosaccharyltransferase Complex Auditory Behavior Regulation Of Long-term Synaptic Depression G Protein-coupled Glutamate Receptor Signaling Pathway Mechanosensory Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Protein N-linked Glycosylation Via Asparagine Cellular Response To Stress Positive Regulation Of Long-term Synaptic Potentiation Proteasomal Protein Catabolic Process Postsynaptic Specialization Organization Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity	Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Regulation Of Endocytosis Regulation Of Transport Monoamine Transport
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