CTLA4 and ATP5MC3

		CTLA4	ATP5MC3
Description		cytotoxic T-lymphocyte associated protein 4	ATP synthase membrane subunit c locus 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting ATP Synthase Complex
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Proton Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response DNA Damage Response Negative Regulation Of B Cell Proliferation Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Transmembrane Transport
Pathways		Co-stimulation by CD28 Co-inhibition by CTLA4 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs		Abatacept Ipilimumab Tremelimumab
Diseases		Graves' disease Allograft rejection Type I diabetes mellitus Hashimoto's thyroiditis
GWAS		Addison's disease ( 33574239) Alopecia areata ( 25608926 20596022) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 30572963 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691 27182965) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 24390342 30423114 30572963 23143596 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 19430480 30659077 30572963 25751624 21829393 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		17 interacting genes: AP1M1 AP2M1 CD80 CD86 CTXN3 FYN JAK2 LCK LYN MALL PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TMEM218 TXK	4 interacting genes: ABHD16A GLP1R MTNR1A VKORC1
Entrez ID		1493	518
HPRD ID		00474	04112
Ensembl ID		ENSG00000163599	ENSG00000154518
Uniprot IDs		P16410	P48201
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO 7DV4 7ELX 7SU0 7SU1 8GAB 8HIT 9DQ3
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Growth Hormone Receptor Signaling Pathway Leukocyte Activation T Cell Activation Lymphocyte Activation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Interleukin-2 Production Regulation Of Mononuclear Cell Proliferation Regulation Of Immune Response Positive Regulation Of Leukocyte Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Leukocyte Proliferation Phosphatidylinositol 3-kinase Binding Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell Activation Positive Regulation Of Immune Response Protein Tyrosine Kinase Activity Regulation Of Interleukin-2 Production Positive Regulation Of Cytokine Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Hemopoiesis Regulation Of Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activated T Cell Proliferation Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Mononuclear Cell Differentiation Peptide Hormone Receptor Binding Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Proliferation Regulation Of Lymphocyte Differentiation	Glucagon-like Peptide 1 Receptor Activity Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glucagon Receptor Activity Protein Complex Involved In Cell Adhesion Response To Psychosocial Stress Melatonin Receptor Activity Monoacylglycerol Catabolic Process Negative Regulation Of Regulatory T Cell Differentiation
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