GLIS1 and SPRR1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLIS1	SPRR1A
Description		GLIS family zinc finger 1	small proline rich protein 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cornified Envelope Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29313844 29691431) Mitral valve prolapse ( 26301497) Monobrow ( 27182965) Nicotine use ( 23942779) Non-substance related behavioral disinhibition ( 23942779) Nose size ( 27182965) Refractive error ( 32231278) Response to statin therapy ( 20339536)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		13 interacting genes: ARNT CDK6 CDKN2A GLIS2 LATS2 MYC NFIC RELA SOX3 SPRR1A TCF3 TEAD2 ZDHHC23	2 interacting genes: ACTA1 GLIS1
Entrez ID		148979	6698
HPRD ID		13581	01647
Ensembl ID		ENSG00000174332	ENSG00000169474
Uniprot IDs		A0A0D9SEX9 Q8NBF1	P35321
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Regulation Of Protein Sumoylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Cellular Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Developmental Process Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Monocyte Differentiation Regulation Of Developmental Process DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Keratinocyte Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Regulator Complex Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Sumoylation Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epidermal Cell Differentiation Nucleoplasm Negative Regulation Of Biosynthetic Process	Mesenchyme Migration Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor III Complex Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Skeletal Muscle Thin Filament Assembly Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Striated Muscle Thin Filament Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Neutrophil Activation Involved In Immune Response Serotonin Transport IgG Binding Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myeloid Cell Apoptotic Process Plasma Membrane Protein Complex Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Biosynthetic Process Negative Regulation Of Myeloid Cell Apoptotic Process Skeletal Muscle Fiber Development Cellular Developmental Process Myotube Cell Development Myosin Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production Cellular Response To Low-density Lipoprotein Particle Stimulus Monoamine Transport Positive Regulation Of Acute Inflammatory Response Mast Cell Degranulation Phagocytosis, Engulfment Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neutrophil Activation
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