GLIS1 and ZDHHC23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLIS1	ZDHHC23
Description		GLIS family zinc finger 1	zDHHC palmitoyltransferase 23
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29313844 29691431) Mitral valve prolapse ( 26301497) Monobrow ( 27182965) Nicotine use ( 23942779) Non-substance related behavioral disinhibition ( 23942779) Nose size ( 27182965) Refractive error ( 32231278) Response to statin therapy ( 20339536)	Crohn's disease and psoriasis ( 22482804)
Interacting Genes		13 interacting genes: ARNT CDK6 CDKN2A GLIS2 LATS2 MYC NFIC RELA SOX3 SPRR1A TCF3 TEAD2 ZDHHC23	3 interacting genes: APP GLIS1 NOS1
Entrez ID		148979	254887
HPRD ID		13581	15717
Ensembl ID		ENSG00000174332	ENSG00000184307
Uniprot IDs		A0A0D9SEX9 Q8NBF1	A0A1W2PRJ8 B3KXV3 E9PAP7 Q8IYP9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Regulation Of Protein Sumoylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Cellular Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Developmental Process Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Monocyte Differentiation Regulation Of Developmental Process DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Keratinocyte Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Regulator Complex Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Sumoylation Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epidermal Cell Differentiation Nucleoplasm Negative Regulation Of Biosynthetic Process	Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Neurotransmitter Uptake Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Calcium-mediated Signaling Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity Positive Regulation Of Macromolecule Metabolic Process Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Calcium Ion Transport Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction Cadmium Ion Binding
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