PIK3R6 and PIK3CG

Number of citations of the paper that reports this interaction (PubMedID 16476736)
0

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		PIK3R6	PIK3CG
Description		phosphoinositide-3-kinase regulatory subunit 6	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Identical Protein Binding Ephrin Receptor Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Protein Serine Kinase Activity
	Biological Process	Angiogenesis Immune Response G Protein-coupled Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of MAP Kinase Activity Positive Regulation Of T Cell Differentiation Positive Regulation Of Angiogenesis	Angiogenesis Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Endothelial Cell Migration T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Cell Migration Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Cellular Response To CAMP Neutrophil Extravasation Hepatocyte Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Fibroblast Apoptotic Process
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Co-stimulation by ICOS	GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Co-stimulation by ICOS
Drugs			Staurosporine Myricetin LY-294002 Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE Wortmannin 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Duvelisib Fostamatinib
Diseases
GWAS			Antisaccade task score ( 31596458) Blood pressure ( 21909110) Carotid intima media thickness ( 21909108 30510157) Carotid plaque ( 30510157) Mean platelet volume ( 22423221 19820697 22139419 28031487 24026423) Metabolite levels ( 23823483) Platelet aggregation ( 29185836) Platelet count ( 22139419 22423221 29066854 29403010) Pulse pressure ( 29403010 30487518 26390057 28739976 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		1 interacting genes: PIK3CG	22 interacting genes: CD28 EPHA8 GAB1 GRB2 GRK2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PIK3R6 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		146850	5294
HPRD ID		12682	03135
Ensembl ID		ENSG00000276231	ENSG00000105851
Uniprot IDs		B3KRK9 Q5UE93	A8K9G9 P48736
PDB IDs			1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4HVB 4J6I 4KZ0 4KZC 4PS3 4PS7 4PS8 4URK 4WWN 4WWO 4WWP 4XX5 4XZ4 5EDS 5G2N 5G55 5JHA 5JHB 5KAE 5OQ4 5T23 6AUD 6C1S 6FH5 6GQ7 6T3B 6T3C 6XRL 6XRM 6XRN 7JWE 7JWZ 7JX0 7KKE 7MEZ 7Z61 8DP0 8SC8 9GG9
Enriched GO Terms of Interacting Partners?		Hepatocyte Apoptotic Process 1-phosphatidylinositol-3-kinase Activity Natural Killer Cell Chemotaxis Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Cardiac Muscle Contraction Secretory Granule Localization Phosphatidylinositol 3-kinase Complex, Class IB Dendritic Cell Migration Negative Regulation Of Blood Circulation Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Rac Protein Signal Transduction Respiratory Burst Involved In Defense Response Phosphatidylinositol-3-phosphate Biosynthetic Process Dendritic Cell Chemotaxis Phosphatidylinositol-mediated Signaling T Cell Chemotaxis Negative Regulation Of Muscle Contraction Phosphatidylinositol 3-kinase Complex Negative Regulation Of Triglyceride Catabolic Process Respiratory Burst 1-phosphatidylinositol-4-phosphate 3-kinase Activity Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Triglyceride Metabolic Process Mast Cell Degranulation Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Heart Contraction Sphingosine-1-phosphate Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Lymphocyte Chemotaxis 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Sphingolipid Mediated Signaling Pathway Negative Regulation Of Lipid Catabolic Process Neutrophil Extravasation Cellular Extravasation Inner Dynein Arm Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Axonemal Dynein Complex Dynein Light Intermediate Chain Binding Ephrin Receptor Binding Positive Regulation Of MAP Kinase Activity Regulation Of Rac Protein Signal Transduction Cell Motility T Cell Migration 9+2 Motile Cilium Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Dynein Complex Leukocyte Degranulation Regulation Of Triglyceride Metabolic Process	T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol 3-kinase Complex Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Phosphatidylinositol 3-kinase Complex, Class IA Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Regulation Of Cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Activation Positive Regulation Of Cell Population Proliferation Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Glial Cell Development Positive Regulation Of Gliogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Ras Protein Signal Transduction Regulation Of Multicellular Organismal Development Response To Mechanical Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Programmed Cell Death Immune System Process Plasma Membrane Cell Development Immune Response Regulation Of Gliogenesis Positive Regulation Of Gene Expression Positive Regulation Of Neurogenesis Regulated Exocytosis
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