ZNF597 and TAOK2

		ZNF597	TAOK2
Description		zinc finger protein 597	TAO kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Focal Adhesion Assembly Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization
Pathways		Generic Transcription Pathway
Drugs			Dexfosfoserine Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 30285260 29483656 28991256 25056061) Triglyceride levels ( 32154731 32203549) Waist circumference ( 31928498)
Interacting Genes		6 interacting genes: CIB3 IRAK4 SYT17 TRIM55 TRIM63 ZDHHC17	12 interacting genes: CIDEB ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MEGF10 RCHY1 TUBA1A TUBA4A TUBB USF1
Entrez ID		146434	9344
HPRD ID		15869	18147
Ensembl ID		ENSG00000167981	ENSG00000149930
Uniprot IDs		Q96LX8	Q9UL54
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitogen-activated Protein Kinase Kinase Binding Cell Projection Morphogenesis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Basal Dendrite Morphogenesis Dendrite Arborization Intracellular Signaling Cassette Cell Migration Regulation Of Intracellular Signal Transduction Dendritic Growth Cone Axonogenesis Neuron Projection Morphogenesis Transferase Activity Positive Regulation Of Signaling Cytoplasmic Vesicle Membrane MAPK Cascade Regulation Of Cell Morphogenesis Basal Dendrite Arborization Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Golgi Apparatus Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Toll Signaling Pathway Innate Immune Response Interleukin-1 Receptor Binding Magnesium Ion Binding Myeloid Leukocyte Migration Leukocyte Migration Defense Response To Other Organism Extrinsic Component Of Plasma Membrane Interleukin-33-mediated Signaling Pathway Toll-like Receptor 9 Signaling Pathway Defense Response To Symbiont Diapedesis Muscle Atrophy Titin Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Contractile Muscle Fiber Striated Muscle Atrophy Neuron Projection Arborization Positive Regulation Of Stress-activated MAPK Cascade Neuropilin Binding Cell Motility Lipoprotein Transport	Response To Light Stimulus NLRP1 Inflammasome Complex Assembly Response To Radiation Cellular Response To UV-B MAP Kinase Kinase Activity COPII Vesicle Coat Structural Constituent Of Cytoskeleton Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade
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