PRIMA1 and ACHE

Number of citations of the paper that reports this interaction (PMID 11804574)
40

Data Source:
HPRD (in vivo)

		PRIMA1	ACHE
Gene Name		proline rich membrane anchor 1	acetylcholinesterase (Yt blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Cell Junction Intrinsic Component Of Plasma Membrane Synapse	Extracellular Region Basal Lamina Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Anchored Component Of Membrane Neuromuscular Junction Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Enzyme Binding Protein Anchor	Beta-amyloid Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association
	Biological Process	Neurotransmitter Catabolic Process Establishment Of Localization In Cell	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development DNA Replication Acetylcholine Catabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Synaptic Transmission Nervous System Development Synapse Assembly Muscle Organ Development Cell Proliferation Response To Wounding Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Small Molecule Metabolic Process Neurotransmitter Receptor Biosynthetic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Secretion Protein Tetramerization Retina Development In Camera-type Eye
Pathways			Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses
Drugs			Choline Tacrine Gallamine Triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Ephedrine Neostigmine Monoisopropylphosphorylserine Huperaine A Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium Methylphosphonic Acid Ester Group Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose 2-(N-Morpholino)-Ethanesulfonic Acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
Diseases
GWAS		Insomnia (caffeine-induced) ( 22754043)	Heart rate ( 23583979) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 21490949)
Protein-Protein Interactions		1 interactors: ACHE	9 interactors: APP COL1A1 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		145270	43
HPRD ID		17907	00010
Ensembl ID		ENSG00000175785	ENSG00000087085
Uniprot IDs		Q86XR5	P22303
PDB IDs			1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Acetylcholine Catabolic Process Acetylcholine Catabolic Process In Synaptic Cleft Receptor Biosynthetic Process Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Metabolic Process Neurotransmitter Catabolic Process Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Phosphatidylcholine Biosynthetic Process Neurotransmitter Metabolic Process Regulation Of Receptor Recycling Osteoblast Development Receptor Internalization Phosphatidylcholine Metabolic Process Negative Regulation Of Synaptic Transmission Synapse Assembly Receptor Metabolic Process Protein Tetramerization Cellular Biogenic Amine Metabolic Process Amine Metabolic Process Regulation Of Neurotransmitter Levels Osteoblast Differentiation Retina Development In Camera-type Eye Synapse Organization Positive Regulation Of Protein Secretion Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process DNA Replication Muscle Organ Development Ossification Glycerophospholipid Metabolic Process Regulation Of Synaptic Transmission Positive Regulation Of Secretion Positive Regulation Of Protein Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Camera-type Eye Development Glycerolipid Metabolic Process Phospholipid Metabolic Process Regulation Of Protein Secretion Eye Development Protein Oligomerization	Extracellular Matrix Organization Extracellular Structure Organization Retinal Blood Vessel Morphogenesis Extracellular Matrix Disassembly Axon Guidance Retina Vasculature Morphogenesis In Camera-type Eye Neurotransmitter Catabolic Process Odontogenesis Blood Vessel Development Axonogenesis Vasculature Development Retina Vasculature Development In Camera-type Eye Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Chemotaxis Neurotransmitter Metabolic Process Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Head Development Neuron Projection Development Cell Projection Morphogenesis Neuromuscular Junction Development Cell Part Morphogenesis Cardiovascular System Development Tissue Development Cellular Response To Amino Acid Stimulus Organ Development Response To External Stimulus Collagen Catabolic Process Neuron Development Epithelial Tube Morphogenesis Organ Morphogenesis Embryonic Heart Tube Formation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Cellular Response To Fluoride Collagen Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Blood Vessel Morphogenesis Tube Morphogenesis Cell Differentiation Multicellular Organismal Metabolic Process Neuron Differentiation Cell Projection Organization Morphogenesis Of An Epithelium
Tagcloud ?		arguing buthionine cdkn1a del17p depleted dr5 glutamylcysteine glutathione gsh hmcls irreversible jjn3 ld50 lethal massive met mum myeloma neg noxa overcame reactivation silencing sulphoximine synergized synthetase tnfrsf10b tp53	acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening
Tagcloud (Difference) ?		arguing buthionine cdkn1a del17p depleted dr5 glutamylcysteine glutathione gsh hmcls jjn3 lethal massive met mum myeloma neg noxa overcame reactivation silencing sulphoximine synergized synthetase tnfrsf10b tp53	acetylcholinesterase amphetamine atropine bring ceb diazepam drl mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening
Tagcloud (Intersection) ?		irreversible ld50