SMCR8 and ATG13

Number of citations of the paper that reports this interaction (PubMedID 30669939)
71

Data Source:
BioGRID (two hybrid)

		SMCR8	ATG13
Description		SMCR8-C9orf72 complex subunit	autophagy related 13
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Cell Projection Synapse Presynapse Postsynapse Atg1/ULK1 Kinase Complex	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Membrane Cytosol Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Kinase Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Negative Regulation Of Exocytosis Negative Regulation Of Immune Response Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling	Autophagosome Assembly Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Regulation Of Cell Population Proliferation Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)	Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)
Interacting Genes		4 interacting genes: ATG13 FEM1B TBK1 ULK1	13 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C OTOS RNF31 SMCR8 ULK1
Entrez ID		140775	9776
HPRD ID		18075	13809
Ensembl ID		ENSG00000176994	ENSG00000175224
Uniprot IDs		Q8TEV9	A8K0S6 O75143
PDB IDs		6LT0 6V4U 7EL6 7MGE 7O2W	3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN 8DO8 8SOI 8SQZ 8SRM 9C82
Enriched GO Terms of Interacting Partners?		Atg1/ULK1 Kinase Complex Phagophore Assembly Site Membrane Positive Regulation Of Autophagy Macroautophagy Microautophagy Nucleophagy Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Peptidyl-serine Phosphorylation Autophagy Mitophagy Regulation Of Autophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Catabolic Process Omegasome Membrane Epithelial Cell Maturation Involved In Prostate Gland Development Dendritic Cell Proliferation Intracellular Protein Localization Vacuole Organization Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Macroautophagy Catabolic Process Response To Mitochondrial Depolarisation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway T Follicular Helper Cell Differentiation Negative Regulation Of Collateral Sprouting Branching Involved In Prostate Gland Morphogenesis Regulation Of TORC2 Signaling	Mitophagy Autophagosome Membrane Autophagosome Organization Autophagosome Assembly Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Autophagosome Autophagy Vacuole Organization Autophagosome Maturation Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Cellular Response To Starvation Phospholipid Binding Organelle Assembly Response To Nutrient Levels Ubiquitin Protein Ligase Binding Atg1/ULK1 Kinase Complex Cytoplasmic Vesicle Catabolic Process Protein-containing Complex Organization GABA Receptor Binding Cellular Component Assembly Phagophore Assembly Site Positive Regulation Of Catabolic Process Microtubule Beta-tubulin Binding Cellular Response To Stress Organelle Membrane Regulation Of Autophagy Response To Stress Positive Regulation Of Autophagy Regulation Of Macroautophagy Organelle Organization Microtubule Binding Endomembrane System Positive Regulation Of Macroautophagy Response To Lead Ion Axoneme Cytosol Phagophore Assembly Site Membrane Cellular Response To Copper Ion Cytoplasm Response To Copper Ion GTPase Binding Regulation Of Autophagosome Assembly Amyloid-beta Complex
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