PACRG and MEIG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PACRG	MEIG1
Description		parkin coregulated	meiosis/spermiogenesis associated 1
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GO Annotations	Cellular Component	Manchette Nucleus Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Cilium Motile Cilium Vesicle Sperm Flagellum Cell Projection Neuron Projection Cell Body Sperm Midpiece Glial Cell Projection Axonemal B Tubule Inner Sheath	Manchette Nucleus Cytosol
	Molecular Function	G Protein-coupled Receptor Binding Actin Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding Beta-tubulin Binding Protein-folding Chaperone Binding Hsp90 Protein Binding	Protein Binding
	Biological Process	Spermatid Development Intracellular Protein Localization Flagellated Sperm Motility Cellular Response To Unfolded Protein	Spermatogenesis Sperm Axoneme Assembly Intracellular Protein Localization Cell Differentiation Manchette Assembly
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Paracentral lobule volume ( 31530798) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary vesicoureteric reflux ( 29097723) Schizophrenia and type 2 diabetes ( 30470734)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		3 interacting genes: APP FBXO7 MEIG1	3 interacting genes: NCOA5 PACRG SPAG16
Entrez ID		135138	644890
HPRD ID		07465	18975
Ensembl ID		ENSG00000112530	ENSG00000197889
Uniprot IDs		Q96M98	Q5JSS6
PDB IDs		6NDU 6NEP 6UCC 7UNG 8J07	6NDU 6NEP 6UCC
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Regulation Of Neuron Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Protein Heterodimerization Activity Manchette Assembly Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Apoptotic Signaling Pathway Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation	Sperm Flagellum Cilium Movement Motile Cilium Axonemal Central Apparatus Mucociliary Clearance Microtubule-based Movement Axonemal B Tubule Inner Sheath Cerebrospinal Fluid Circulation Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cilium Extracellular Transport Epithelial Cilium Movement Involved In Extracellular Fluid Movement Respiratory System Process Microtubule-based Process Sperm Axoneme Assembly Developmental Process Involved In Reproduction Cellular Response To Unfolded Protein Alpha-tubulin Binding Axonemal Microtubule Cellular Response To Topologically Incorrect Protein Glial Cell Projection Hsp90 Protein Binding Beta-tubulin Binding Hsp70 Protein Binding Sperm Midpiece Manchette Axoneme Assembly
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