BBS5 and EIF4EBP3

		BBS5	EIF4EBP3
Description		Bardet-Biedl syndrome 5	eukaryotic translation initiation factor 4E binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Ciliary Membrane	Nucleus Cytoplasm Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	Heart Looping Visual Perception Protein Transport Cell Projection Organization Melanosome Transport Motile Cilium Assembly Intracellular Transport Cilium Assembly	Regulation Of Translation Negative Regulation Of Translation Negative Regulation Of Translational Initiation
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Iris heterochromicity ( 30895295)	Metabolite levels ( 23823483) Serum immune biomarker levels ( 32066700)
Interacting Genes		4 interacting genes: CRADD KLC3 TOM1 TOM1L2	2 interacting genes: EIF4E EIF4E2
Entrez ID		129880	8637
HPRD ID		10353	09149
Ensembl ID		ENSG00000163093	ENSG00000243056
Uniprot IDs		A0A0S2Z626 Q8N3I7	O60516
PDB IDs		6XTB
Enriched GO Terms of Interacting Partners?			MRNA Cap Binding RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Translation Initiation Factor Activity Translational Initiation P-body Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Translation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Translation BBSome Regulation Of Translation Chromatoid Body Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Negative Regulation Of Type I Interferon-mediated Signaling Pathway Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Melanosome Transport Pigment Granule Localization Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Rescue Of Stalled Ribosome
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