COL6A2 and ABCD3

Number of citations of the paper that reports this interaction (PubMedID 12176987)
0

Data Source:
HPRD (in vivo)

		COL6A2	ABCD3
Description		collagen type VI alpha 2 chain	ATP binding cassette subfamily D member 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Sarcolemma Extracellular Exosome Extracellular Vesicle	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity
	Biological Process	Cell Adhesion Response To UV Response To Glucose Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Apoptotic Process	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Lipid Transport Peroxisome Organization Response To Xenobiotic Stimulus Bile Acid And Bile Salt Transport Long-chain Fatty Acid Import Into Peroxisome Very Long-chain Fatty Acid Catabolic Process Transmembrane Transport Phytanic Acid Metabolic Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	ABC transporters in lipid homeostasis RHOA GTPase cycle RHOC GTPase cycle Class I peroxisomal membrane protein import
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Height ( 31562340) Intraocular pressure ( 29235454) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: ABCD3 COX6A2 FN1 SIRPA SLC38A3	7 interacting genes: ABCD1 ABCD2 COL6A2 PEX19 PSMA1 TUFT1 UBC
Entrez ID		1292	5825
HPRD ID		02110	01368
Ensembl ID		ENSG00000142173	ENSG00000117528
Uniprot IDs		A0A384MDP3 P12110	P28288
PDB IDs			8Z0F 8Z9X
Enriched GO Terms of Interacting Partners?		Regulation Of Extracellular Matrix Organization Positive Regulation Of Cell Adhesion Core-binding Factor Complex Tissue Regeneration Collagen Binding Collagen Type VI Trimer Basement Membrane Endodermal Cell Differentiation Multicellular Organismal Locomotion Response To Polyamine Macromolecule Response To Activity Response To Muscle Activity Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Phytanic Acid Metabolic Process Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Cellular Response To Potassium Ion Starvation Asparagine Transport Asparagine Transmembrane Transport Positive Regulation Of Glutamine Transport Glutamine Secretion L-asparagine, Sodium:proton Antiporter Activity L-asparagine Transmembrane Transporter Activity Histidine Transport L-histidine Import Across Plasma Membrane L-glutamine, Sodium:proton Antiporter Activity L-asparagine Import Across Plasma Membrane L-histidine, Sodium:proton Antiporter Activity Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Cellular Response To Interleukin-12 Cardiac Muscle Tissue Regeneration Ossification Regeneration Calcium-independent Cell-matrix Adhesion Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome L-histidine Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Neutral L-amino Acid:sodium Symporter Activity L-glutamine Import Across Plasma Membrane L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Monocyte Extravasation Response To Reactive Oxygen Species Regulation Of Cell Activation Response To Bleomycin Apoptotic Nuclear Changes	Peroxisomal Membrane Transport Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Peroxisome Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Long-chain Fatty Acid Import Into Peroxisome Fatty Acid Beta-oxidation Peroxisomal Membrane Very Long-chain Fatty Acid Catabolic Process Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Fatty Acid Oxidation Fatty Acyl-CoA Hydrolase Activity Myelin Maintenance Alpha-linolenic Acid Metabolic Process Peroxisome Long-chain Fatty Acid Transmembrane Transporter Activity Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Lipid Modification Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipid Catabolic Process ATPase-coupled Transmembrane Transporter Activity Regulation Of Fatty Acid Oxidation Carboxylic Acid Catabolic Process Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process ABC-type Transporter Activity Regulation Of Reactive Oxygen Species Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Organization Lipid Catabolic Process Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Fatty Acid Biosynthetic Process Long-chain Fatty Acid Transport Fatty Acid Derivative Biosynthetic Process Fatty Acid Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Small Molecule Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process ABC-type Fatty-acyl-CoA Transporter Activity
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