ARL8A and UQCRH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL8A	UQCRH
Description		ARF like GTPase 8A	ubiquinol-cytochrome c reductase hinge protein
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Spindle Cytoskeleton Plasma Membrane Membrane Axon Midbody Late Endosome Membrane Azurophil Granule Membrane Cell Projection Synapse Spindle Midzone Extracellular Exosome Ficolin-1-rich Granule Membrane Axon Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Alpha-tubulin Binding Beta-tubulin Binding	Protein Binding Quinol-cytochrome-c Reductase Activity
	Biological Process	Chromosome Segregation Anterograde Axonal Transport Protein Transport Cell Division	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration Proton Transmembrane Transport
Pathways		Neutrophil degranulation	Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS			Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: PUF60 UQCRH	7 interacting genes: ARL8A ENTREP3 NDFIP1 NDFIP2 NPM1 PRRG1 RNF24
Entrez ID		127829	7388
HPRD ID		09807	15629
Ensembl ID		ENSG00000143862	ENSG00000173660
Uniprot IDs		A0A087X2J2 Q96BM9	P07919 Q567R0
PDB IDs		1ZD9 2H18 4ILE	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?			WW Domain Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Post-translational Protein Modification Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Protein Modification Process Intracellular Transport Regulation Of Endoribonuclease Activity Negative Regulation Of Protein Transport Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Cellular Localization Regulation Of Protein Modification Process Positive Regulation Of Centrosome Duplication Establishment Of Localization In Cell Membrane Golgi Membrane Negative Regulation Of Establishment Of Protein Localization Vacuolar Transport Negative Regulation Of Isotype Switching Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Endosome Negative Regulation Of Interleukin-4 Production Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Tat Protein Binding Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization Ribosomal Subunit Export From Nucleus Negative Regulation Of Centrosome Duplication Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Immunoglobulin Production Spindle Pole Centrosome Ribosomal Large Subunit Binding Endosome Membrane Alpha-beta T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Type 2 Immune Response
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