ADH4 and RPL35

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADH4	RPL35
Description		alcohol dehydrogenase 4 (class II), pi polypeptide	ribosomal protein L35
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleolus Cytoplasm Cytosol Ribosome Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Ribonucleoprotein Complex
	Molecular Function	Quinone Reductase (NADPH) Activity Alcohol Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity All-trans-retinol Dehydrogenase (NAD+) Activity All-trans Retinal Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Benzaldehyde Dehydrogenase (NAD+) Activity Retinol Binding Metal Ion Binding NAD Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome
	Biological Process	Retinoid Metabolic Process Alcohol Metabolic Process Ethanol Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Fatty Acid Omega-oxidation Retinol Metabolic Process Alcohol Catabolic Process Formaldehyde Catabolic Process Quinone Metabolic Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cytoplasmic Translation Translation
Pathways		RA biosynthesis pathway Ethanol oxidation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		NADH Cyclohexylformamide	Artenimol
Diseases
GWAS		Alcohol dependence ( 23456092 24166409 33290381) Alcohol use disorder ( 30940813) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Esophageal cancer (alcohol interaction) ( 22960999) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Liver enzyme levels (alkaline phosphatase) ( 33972514) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33339817 33547301) Serum metabolite levels ( 24625756) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: APP RPL35	11 interacting genes: ACTN2 ADH4 CDKN1A CREBBP DUX4 FOXP1 LAMC3 MAX PDE4B SGSM3 TUBB2B
Entrez ID		127	11224
HPRD ID		00068	10200
Ensembl ID		ENSG00000198099	ENSG00000136942
Uniprot IDs		P08319 V9HVX7	P42766
PDB IDs		3COS	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8ONY 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process
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