ADH4

Description		alcohol dehydrogenase 4 (class II), pi polypeptide
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Quinone Reductase (NADPH) Activity Alcohol Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity All-trans-retinol Dehydrogenase (NAD+) Activity All-trans Retinal Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Benzaldehyde Dehydrogenase (NAD+) Activity Retinol Binding Metal Ion Binding NAD Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity
	Biological Process	Retinoid Metabolic Process Alcohol Metabolic Process Ethanol Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Fatty Acid Omega-oxidation Retinol Metabolic Process Alcohol Catabolic Process Formaldehyde Catabolic Process Quinone Metabolic Process
Pathways		RA biosynthesis pathway Ethanol oxidation
Drugs		NADH Cyclohexylformamide
Diseases
GWAS		Alcohol dependence ( 23456092 24166409 33290381) Alcohol use disorder ( 30940813) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Esophageal cancer (alcohol interaction) ( 22960999) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Liver enzyme levels (alkaline phosphatase) ( 33972514) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33339817 33547301) Serum metabolite levels ( 24625756) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: APP RPL35
Entrez ID		127
HPRD ID		00068
Ensembl ID		ENSG00000198099
Uniprot IDs		P08319 V9HVX7
PDB IDs		3COS
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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