ACER1 and TMIGD2

		ACER1	TMIGD2
Description		alkaline ceramidase 1	transmembrane and immunoglobulin domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane Neuron Projection
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Metal Ion Binding	Protein Binding Coreceptor Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Epidermis Development Response To Alkaline PH Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Cell Differentiation Keratinocyte Differentiation Sphingosine Biosynthetic Process Ceramide Catabolic Process Sebaceous Gland Development Cellular Response To Calcium Ion	Positive Regulation Of Cytokine Production T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Angiogenesis
Pathways		Sphingolipid catabolism
Drugs
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715)	Post-bronchodilator lung function in asthma (FVC) ( 32989782)
Interacting Genes		1 interacting genes: MPP1
Entrez ID		125981	126259
HPRD ID		12496	14487
Ensembl ID		ENSG00000167769	ENSG00000167664
Uniprot IDs		Q8TDN7	A0A0B4J2A9 Q96BF3
PDB IDs
Enriched GO Terms of Interacting Partners?		GMP Kinase Activity GDP Metabolic Process Stereocilium Regulation Of Neutrophil Chemotaxis Cortical Cytoskeleton GMP Metabolic Process Regulation Of Neutrophil Migration Positive Regulation Of Activated T Cell Proliferation T Cell Costimulation Regulation Of Activated T Cell Proliferation Regulation Of Granulocyte Chemotaxis	Sphingosine Biosynthetic Process Response To Alkaline PH Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Sebaceous Gland Development Sphingoid Biosynthetic Process MICOS Complex Mitochondrial Crista Junction SAM Complex Cristae Formation MIB Complex Sphingosine Metabolic Process Ceramide Catabolic Process Diol Metabolic Process
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