AFMID and MED18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AFMID	MED18
Description		arylformamidase	mediator complex subunit 18
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Arylformamidase Activity Protein Binding Hydrolase Activity	Transcription Coregulator Activity Protein Binding
	Biological Process	L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine 'de Novo' NAD+ Biosynthetic Process From L-tryptophan	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Tryptophan catabolism	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Vitiligo ( 27723757)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
Interacting Genes		4 interacting genes: CFTR DDIT4L MED18 MEI4	9 interacting genes: AFMID CAMK2B HOMEZ MED20 MED31 MED9 TEPSIN TRIM39 USP49
Entrez ID		125061	54797
HPRD ID		16478	17476
Ensembl ID		ENSG00000183077	ENSG00000130772
Uniprot IDs		Q63HM1	Q9BUE0
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Meiotic DNA Double-strand Break Formation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Lateral Element Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation	Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Protein-DNA Complex Assembly Arylformamidase Activity Coated Vesicle Membrane Histone H2B Deubiquitinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex L-tryptophan Catabolic Process To Kynurenine
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