GGT6 and PIGS

		GGT6	PIGS
Description		gamma-glutamyltransferase 6	phosphatidylinositol glycan anchor biosynthesis class S
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity	Protein Binding
	Biological Process	Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene D4 Biosynthetic Process	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME	Attachment of GPI anchor to uPAR
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524)
Interacting Genes		10 interacting genes: ADAM33 BMP10 ENTPD3 FAIM2 FAM3C GRINA NOTCH3 SEC22A TMBIM1 TNMD	14 interacting genes: CPEB2 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP6-3 KRTAP9-2 NBPF19 NOTCH2NLA TRIP6
Entrez ID		124975	94005
HPRD ID		08293	15135
Ensembl ID		ENSG00000167741	ENSG00000087111
Uniprot IDs		B4DKN3 B4DPG6 J3KPJ0 Q6P531 Q6ZPD7	Q8NBL9 Q96IR5 Q96S52
PDB IDs			7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Calcium Channel Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Calcium Ion Transmembrane Transport Golgi Membrane Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Apoptotic Signaling Pathway Negative Regulation Of Fas Signaling Pathway Apyrase Activity Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Cerebellar Granular Layer Development	Intermediate Filament Keratin Filament
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