AGBL1 and ZNF592

		AGBL1	ZNF592
Description		AGBL carboxypeptidase 1	zinc finger protein 592
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoskeleton	Nucleus
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Tubulin Binding Hydrolase Activity Metal Ion Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding PH Domain Binding Insulin Receptor Substrate Binding Metal Ion Binding
	Biological Process	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation	Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Activated partial thromboplastin time ( 22703881) Acute lymphoblastic leukemia ( 33891562) Acute lymphoblastic leukemia (adult) ( 33891562) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212) Triiodothyronine levels ( 30843173) Venous thromboembolism ( 33592630)	Alzheimer's disease (age of onset) ( 22005931) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756 33263727 34002096) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Schizophrenia ( 29483656)
Interacting Genes			6 interacting genes: BTG3 GRIK1 LAMTOR5 SMAD9 SRPK2 TCAF1
Entrez ID		123624	9640
HPRD ID		07115	10339
Ensembl ID		ENSG00000273540	ENSG00000166716
Uniprot IDs		A0A1B0GVQ2 Q96MI9	Q92610
PDB IDs
Enriched GO Terms of Interacting Partners?		PH Domain Binding Signal Peptide Processing Signal Peptidase Complex Insulin Receptor Substrate Binding
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