CCR6 and AASS

		CCR6	AASS
Description		C-C motif chemokine receptor 6	aminoadipate-semialdehyde synthase
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Transcription Corepressor Activity Catalytic Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Oxidoreductase Activity Histone Binding Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity
	Biological Process	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Lysine Catabolic Process L-lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events	Lysine catabolism
Drugs			Glutamic acid NADH NADPH L-Saccharopine
Diseases			Hyperlysinemia
GWAS		Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 18587394 23850713 21102463 20570966) Graves' disease ( 22922229) Inflammatory bowel disease ( 23128233 27569725 28067908) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 32723749 24390342 23143596 20453841) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 27723757 20526339)	Opioid dependence (time to event) ( 34124712)
Interacting Genes		5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1	2 interacting genes: OGT WEE2-AS1
Entrez ID		1235	10157
HPRD ID		03498	05489
Ensembl ID		ENSG00000112486	ENSG00000008311
Uniprot IDs		P51684	A0A7P0T9N4 A4D0W4 Q9UDR5
PDB IDs		6WWZ	5L76 5L78 5O1N 5O1O 5O1P 8DDA 8E8T 8E8U 8E8V
Enriched GO Terms of Interacting Partners?		CCR6 Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Humoral Immune Response Defense Response To Gram-negative Bacterium Locomotion Defense Response To Bacterium Chemotaxis Golgi Lumen Defense Response To Other Organism Defense Response To Gram-positive Bacterium Defense Response To Symbiont Killing Of Cells Of Another Organism Response To Bacterium Chemoattractant Activity Cell Killing Cell Chemotaxis Response To Other Organism Positive Chemotaxis Immune Response Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Response To External Biotic Stimulus Defense Response Phosphatidylinositol-4,5-bisphosphate Binding Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Regulation Of Response To DNA Integrity Checkpoint Signaling Extracellular Space Cell Migration Flavin-dependent Sulfhydryl Oxidase Activity Thymocyte Migration Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Nuclear Speck Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse L-lysine Catabolic Process Negative Regulation Of Translational Elongation Cell Motility Thiol Oxidase Activity Splicing Factor Binding Immune System Process Lysine Catabolic Process Negative Regulation Of Centriole Replication Calcium-mediated Signaling Positive Regulation Of Gene Expression
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