TDRD9 and TRMT61A

		TDRD9	TRMT61A
Description		tudor domain containing 9	tRNA methyltransferase 61A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PiP-body	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Fertilization Transposable Element Silencing Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation
Pathways		PIWI-interacting RNA (piRNA) biogenesis	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494) Schizophrenia ( 25056061)
Interacting Genes		2 interacting genes: CLK1 RNF10	2 interacting genes: TCL1A TRMT6
Entrez ID		122402	115708
HPRD ID		15484	08810
Ensembl ID		ENSG00000156414	ENSG00000166166
Uniprot IDs		Q86WA0 Q8NDG6	Q96FX7
PDB IDs			5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?		Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Matrix Side Of Mitochondrial Inner Membrane MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation
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