TOP1MT and FSHR

Number of citations of the paper that reports this interaction (PMID 15196694)
8

Data Source:
BioGRID (two hybrid)

		TOP1MT	FSHR
Gene Name		topoisomerase (DNA) I, mitochondrial	follicle stimulating hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Replication Fork Protection Complex Mitochondrial Nucleoid	Plasma Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity	Follicle-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation	G-protein Coupled Receptor Signaling Pathway Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Follicle-stimulating Hormone Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Irinotecan Topotecan	Menotropins Follitropin beta Urofollitropin Choriogonadotropin alfa Suramin
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Erectile dysfunction and prostate cancer treatment ( 20932654) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822)
Protein-Protein Interactions		1 interactors: FSHR	20 interactors: ADRBK1 AKT2 APPL1 ARR3 CANX CBX5 FSHB GRK4 GRK6 RNR2 RPS27A S100A10 TOP1 TOP1MT TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		116447	2492
HPRD ID		16214	00639
Ensembl ID		ENSG00000184428	ENSG00000170820
Uniprot IDs		B4DYD2 E5KMK7 Q969P6	F5GZW2 P23945
PDB IDs			1XUN 1XWD 4AY9
Enriched GO Terms of Interacting Partners?		Follicle-stimulating Hormone Signaling Pathway Ovarian Follicle Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Male Gonad Development Male Sex Differentiation Gonad Development Development Of Primary Sexual Characteristics Sex Differentiation Rhythmic Process Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation	Glycogen Biosynthetic Process Viral Protein Processing Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Polysaccharide Metabolic Process Intracellular Transport Of Virus Regulation Of Cell Cycle Arrest Programmed Cell Death Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Death Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Rhythmic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Carbohydrate Biosynthetic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 2 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor 9 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		accumulates alkaloid attributed biologic camptothecin contain d hexacyclic induces inefficacy inside invertebrates lam lamellarin living marine mitochondria mitochondrial mtdna pyrole relaxation religation represents slows supercoil topoisomerase traps vertebrates	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Difference) ?		accumulates alkaloid attributed biologic camptothecin contain d hexacyclic induces inefficacy inside invertebrates lam lamellarin living marine mitochondria mitochondrial mtdna pyrole relaxation religation represents slows supercoil topoisomerase traps vertebrates	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Intersection) ?