CHRNA5 and SEMA7A

		CHRNA5	SEMA7A
Description		cholinergic receptor nicotinic alpha 5 subunit	semaphorin 7A (JohnMiltonHagen blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Cation Channel Complex Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Dopaminergic Synapse Presynapse Neurotransmitter Receptor Complex Cholinergic Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Side Of Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity	Integrin Binding Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission	Osteoblast Differentiation Neural Crest Cell Migration Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Nervous System Development Axon Guidance Olfactory Lobe Development Cell Differentiation Positive Regulation Of Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Axon Extension Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Regulation Of Synapse Maturation
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Other semaphorin interactions Other semaphorin interactions
Drugs		Nicotine Succinylcholine Butabarbital Cisatracurium Ethanol
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 28166215 33909500 22080838 20173748 19300482) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Fagerstrӧm test for nicotine dependence ( 31294817) ICD10 Z72.0: Tobacco use ( 29758381) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 19836008 28604730) Lung cancer ( 18385738 28604730 18780872 18385676 31577861 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 29483656 25056061) Serum albumin levels ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)	Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)
Interacting Genes		1 interacting genes: CHRNB4	1 interacting genes: PLXNC1
Entrez ID		1138	8482
HPRD ID		00334	07081
Ensembl ID		ENSG00000169684	ENSG00000138623
Uniprot IDs		H0YM98 P30532 Q6EWN4	B3KMH6 F5GYX3 O75326
PDB IDs			3NVQ
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Behavioral Response To Nicotine Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Regulation Of Smooth Muscle Contraction Synaptic Membrane Malonate-semialdehyde Dehydrogenase (acetylating) Activity Methylmalonate-semialdehyde Dehydrogenase (acylating, NAD) Activity Regulation Of Neurotransmitter Secretion Regulation Of Postsynaptic Membrane Potential Olfactory Lobe Development Thymine Metabolic Process Thymine Catabolic Process Adult Behavior Monoatomic Ion Channel Activity Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Muscle Contraction L-valine Catabolic Process Locomotory Behavior Valine Metabolic Process Transmembrane Signaling Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Presynapse Postsynaptic Membrane Pyrimidine Nucleobase Catabolic Process Acetylcholine Binding Regulation Of Muscle System Process Response To Acetylcholine Retinal Binding Retinoid Binding Cholinergic Synapse Chemical Synaptic Transmission Retinol Binding Neuron Projection Trans-synaptic Signaling Synaptic Signaling Regulation Of Transmission Of Nerve Impulse Neuropilin Binding	Regulation Of Cell Motility Microtubule Anchoring At Centrosome Positive Regulation Of Cellular Component Organization Cytokine-mediated Signaling Pathway Protein Localization To Non-motile Cilium BBSome Regulation Of Locomotion Photoreceptor Cell Outer Segment Organization Retinal Rod Cell Development Negative Regulation Of Appetite Positive Regulation Of Organelle Assembly Protein Localization To Photoreceptor Outer Segment Positive Regulation Of Multicellular Organismal Process Striatum Development Fat Pad Development Positive Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Erythrocyte Homeostasis Leptin-mediated Signaling Pathway Sensory Processing Dynactin Binding Regulation Of Non-motile Cilium Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Adult Behavior Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Organelle Assembly Cholinergic Synapse Acetylcholine-gated Monoatomic Cation-selective Channel Activity Behavioral Response To Nicotine Acetylcholine Receptor Activity Dopaminergic Synapse Acetylcholine-gated Channel Complex Neurotransmitter Receptor Complex Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of Interleukin-23 Production Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Epithelial Fluid Transport Regulation Of Interleukin-23 Production Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Neutrophil Differentiation Response To Silicon Dioxide Histamine Transport Histamine Secretion Semaphorin Receptor Complex Regulation Of Synapse Pruning
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