CHRNA5

Gene Name		cholinergic receptor, nicotinic, alpha 5 (neuronal)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Cell Junction Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity
	Biological Process	Transport Cation Transport Signal Transduction Synaptic Transmission Ion Transmembrane Transport Behavioral Response To Nicotine Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Lung adenocarcinoma ( 19836008) Lung cancer ( 18385676 18385738 18780872) Nicotine dependence ( 18385739) Pulmonary function ( 21946350) Serum albumin level ( 23022100) Smoking behavior ( 22832964 20418889)
Protein-protein Interactions		1 interactors: CHRNB4
Entrez ID		1138
HPRD ID		00334
Ensembl ID		ENSG00000169684
Uniprot IDs		P30532 Q6EWN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Micturition Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Response To Nicotine Excretion Regulation Of Smooth Muscle Contraction Smooth Muscle Contraction Regulation Of Neurotransmitter Secretion Action Potential Renal System Process Response To Alkaloid Regulation Of Muscle Contraction Adult Behavior Muscle Contraction Locomotory Behavior Muscle System Process Regulation Of Membrane Potential Regulation Of Synaptic Transmission Single-organism Behavior
Tagcloud ?		1x10 9x10 a3 accounts adenocarcinoma b4 chrnb3 clptm1l conducting cyp1a1 dependence genetics gwa mediation nicotine nicotinic personalized rs1051730 rs12914385 rs2736100 rs2853676 rs31489 rs401681 smoking snps tert variations