CHRNA5 and ALDH6A1

		CHRNA5	ALDH6A1
Description		cholinergic receptor nicotinic alpha 5 subunit	aldehyde dehydrogenase 6 family member A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Cation Channel Complex Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Dopaminergic Synapse Presynapse Neurotransmitter Receptor Complex Cholinergic Synapse	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity	RNA Binding Methylmalonate-semialdehyde Dehydrogenase (acylating, NAD) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Malonate-semialdehyde Dehydrogenase (acetylating) Activity
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission	Thymine Catabolic Process Valine Metabolic Process L-valine Catabolic Process Branched-chain Amino Acid Catabolic Process Thymine Metabolic Process Brown Fat Cell Differentiation
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Branched-chain amino acid catabolism
Drugs		Nicotine Succinylcholine Butabarbital Cisatracurium Ethanol	NADH
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 28166215 33909500 22080838 20173748 19300482) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Fagerstrӧm test for nicotine dependence ( 31294817) ICD10 Z72.0: Tobacco use ( 29758381) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 19836008 28604730) Lung cancer ( 18385738 28604730 18780872 18385676 31577861 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 29483656 25056061) Serum albumin levels ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)	Red blood cell count ( 32888494) Red cell distribution width ( 27863252) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: CHRNB4	2 interacting genes: LMO2 OGT
Entrez ID		1138	4329
HPRD ID		00334	04416
Ensembl ID		ENSG00000169684	ENSG00000119711
Uniprot IDs		H0YM98 P30532 Q6EWN4	A0A024R6G4 Q02252
PDB IDs			8XXQ 9IZU 9IZV 9IZW 9IZX
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Behavioral Response To Nicotine Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Regulation Of Smooth Muscle Contraction Synaptic Membrane Malonate-semialdehyde Dehydrogenase (acetylating) Activity Methylmalonate-semialdehyde Dehydrogenase (acylating, NAD) Activity Regulation Of Neurotransmitter Secretion Regulation Of Postsynaptic Membrane Potential Olfactory Lobe Development Thymine Metabolic Process Thymine Catabolic Process Adult Behavior Monoatomic Ion Channel Activity Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Muscle Contraction L-valine Catabolic Process Locomotory Behavior Valine Metabolic Process Transmembrane Signaling Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Presynapse Postsynaptic Membrane Pyrimidine Nucleobase Catabolic Process Acetylcholine Binding Regulation Of Muscle System Process Response To Acetylcholine Retinal Binding Retinoid Binding Cholinergic Synapse Chemical Synaptic Transmission Retinol Binding Neuron Projection Trans-synaptic Signaling Synaptic Signaling Regulation Of Transmission Of Nerve Impulse Neuropilin Binding	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly
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