PWP1 and CKAP4

		PWP1	CKAP4
Description		PWP1 homolog, endonuclein	cytoskeleton associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Golgi Apparatus	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lipid Droplet Cytoskeleton Plasma Membrane Membrane Nuclear Speck Azurophil Granule Membrane Specific Granule Membrane Lamellar Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Histone Chaperone Activity Histone H4K20me3 Reader Activity	RNA Binding Protein Binding
	Biological Process	Chromatin Organization DNA-templated Transcription Regulation Of DNA-templated Transcription RRNA Processing Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Differentiation
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Neutrophil degranulation Post-translational protein phosphorylation RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: APP CUL4B DAPK1 DCAF1 HOXA3 NFYA OGT SMURF1 USP7	15 interacting genes: ASCC2 ATF4 DKK1 HAMP LINC01554 MLH1 MVP NDUFB7 NEIL3 NKX3-1 OGT PLAT THOC7 TSNAX WASHC3
Entrez ID		11137	10970
HPRD ID		11464	16717
Ensembl ID		ENSG00000136045	ENSG00000136026
Uniprot IDs		B4DJV5 Q13610	Q07065
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Metabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Rhythmic Process Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Engulfment Of Target By Autophagosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of ATP Metabolic Process Chromatin Organization Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Protein Localization To Vacuole
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