KRR1 and BBS10

		KRR1	BBS10
Description		KRR1 small subunit processome component	Bardet-Biedl syndrome 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Membrane Small-subunit Processome Intercellular Bridge Ribonucleoprotein Complex	Cilium Cell Projection
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleotide Binding Protein Binding ATP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Visual Perception Intracellular Protein Localization Response To Light Stimulus Neuronal Action Potential Response To Endoplasmic Reticulum Stress Retinal Cone Cell Differentiation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Photoreceptor Cell Differentiation Chaperone-mediated Protein Complex Assembly Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cone Retinal Bipolar Cell Differentiation Non-motile Cilium Assembly
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Atrial fibrillation ( 29892015) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Polycystic ovary syndrome ( 26416764 30566500) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		4 interacting genes: EWSR1 OGT RPS14 SRPK1	12 interacting genes: CSNK1E FRZB HDAC6 MAP3K7 MAPK6 MAPK8IP2 NR4A1 PTK2 RASA1 RGS2 TNFSF11 YAE1
Entrez ID		11103	79738
HPRD ID		11027	08036
Ensembl ID		ENSG00000111615	ENSG00000179941
Uniprot IDs		Q13601	Q8TAM1
PDB IDs		7MQ8 7MQ9
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Organization Protein-containing Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cytoplasmic Translation Protein-RNA Complex Assembly Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Cone Retinal Bipolar Cell Differentiation Retinal Cone Cell Differentiation Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose Retinal Bipolar Neuron Differentiation Retinal Rod Cell Differentiation	Signal Complex Assembly JNK Cascade MAPK Cascade JUN Kinase Binding Signal Transduction Regulation Of Intracellular Signal Transduction MAP Kinase Activity Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Positive Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Amphetamine Regulation Of JNK Cascade Regulation Of Cell Communication Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Signaling Non-canonical Wnt Signaling Pathway Negative Regulation Of Hepatocyte Differentiation Regulation Of Apoptotic Process Negative Regulation Of Growth Protein Kinase Binding Positive Regulation Of Epithelial Cell Migration Ephrin Receptor Signaling Pathway Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Beta-tubulin Binding Response To Amine Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Fc Receptor Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Cell Morphogenesis Cellular Response To Growth Factor Stimulus Kinase Activity Septin Cytoskeleton Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation
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