ATE1 and ACADSB

Data Source: HiPPIP (Novel)

		ATE1	ACADSB
Name		arginyltransferase 1	acyl-CoA dehydrogenase short/branched chain
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Mitochondrial Matrix
	Molecular Function	Arginyl-tRNA--protein Transferase Activity Protein Binding Transferase Activity Acyltransferase Activity	Short-chain 2-methyl Fatty Acyl-CoA Dehydrogenase Activity Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Proteasomal Protein Catabolic Process Protein Arginylation Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Carboxylic Acid Catabolic Process
Pathways		None	Branched-chain amino acid catabolism Mitochondrial protein degradation
Drugs		None	Isoleucine Valproic acid
Diseases		None	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Chronotype ( 30696823 )	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lower body strength ( 27325353 )
Novel Interactors		12 novel interactors: ABRAXAS2 ACADSB ALCAM CTBP2 FAM53B INTS8 NEDD8 NSMCE4A NUP188 PLEKHA1 RBM10 TIMM17B	1 novel interactors: ATE1
Interacting Genes		2 interacting genes: NTAN1 SUV39H1	None recorded
Entrez ID		11101	36
HPRD ID		06979	02626
Ensembl ID		ENSG00000107669	ENSG00000196177
Uniprot IDs		A0A8I5KTH0 A0A8I5KZ24 B3KWA3 B4DK25 B4E107 F5GXE4 F8WAC9 O95260	A0A0S2Z3P9 P45954
PDB IDs		8TZV 8UAU	2JIF
GO Terms Enriched among Interactors		None	Arginyl-tRNA--protein Transferase Activity Protein Arginylation Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Protein Targeting To Vacuole Involved In Autophagy Protein K27-linked Ubiquitination Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Protein K63-linked Ubiquitination Protein Localization To Vacuole Acyltransferase Activity