ACADSB

Name	acyl-CoA dehydrogenase short/branched chain
Structure
Novel Interactors	1 novel interactors: ATE1
Interactors	None recorded
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Short-chain 2-methyl Fatty Acyl-CoA Dehydrogenase Activity Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Carboxylic Acid Catabolic Process
Pathways	Branched-chain amino acid catabolism Mitochondrial protein degradation
Drugs	Isoleucine Valproic acid
Diseases	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lower body strength ( 27325353 )
Entrez ID	36
HPRD ID	02626
Ensembl ID	ENSG00000196177
Uniprot IDs	A0A0S2Z3P9 P45954
PDB IDs	2JIF
GO Terms Enriched among Interactors ?	Arginyl-tRNA--protein Transferase Activity Protein Arginylation Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Protein Targeting To Vacuole Involved In Autophagy Protein K27-linked Ubiquitination Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Protein K63-linked Ubiquitination Protein Localization To Vacuole Acyltransferase Activity