IFT27 and IFT25

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (two hybrid)

		IFT27	IFT25
Description		intraflagellar transport 27	intraflagellar transport 25
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Centrosome Cilium Intraciliary Transport Particle B Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip	Centrosome Cilium Intraciliary Transport Particle B Cell Projection Ciliary Tip
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding Metal Ion Binding
	Biological Process	Kidney Development Intracellular Protein Transport Smoothened Signaling Pathway Spermatogenesis Protein Transport Vesicle-mediated Transport Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Cochlea Development	Skeletal System Development Kidney Development Smoothened Signaling Pathway Spermatogenesis Heart Development Protein Transport Cell Differentiation Lung Development Intraciliary Anterograde Transport Intraciliary Transport Cilium Assembly Left/right Axis Specification
Pathways		Intraflagellar transport Intraflagellar transport	Intraflagellar transport Intraflagellar transport
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes		2 interacting genes: GOLGA2 IFT25	5 interacting genes: GORASP2 IFT27 NUP62 SEC23IP TRAF3
Entrez ID		11020	51668
HPRD ID		11478	12730
Ensembl ID		ENSG00000100360	ENSG00000081870
Uniprot IDs		Q9BW83	Q9Y547 X6R7Y7
PDB IDs			1TVG 1XPW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Glycosylation Cellular Localization Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Lung Development Regulation Of Protein Glycosylation Intracellular Protein Localization Golgi Disassembly Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of CGAS/STING Signaling Pathway Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Asymmetric Cell Division Kinase Activator Activity Left/right Axis Specification Meiotic Spindle Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Intraciliary Transport Particle B Intraciliary Anterograde Transport Positive Regulation Of Glycoprotein Metabolic Process Meiotic Spindle Organization Coronary Vasculature Development Negative Regulation Of Protein Binding Microtubule Nucleation Organelle Assembly CGAS/STING Signaling Pathway Protein Exit From Endoplasmic Reticulum Non-canonical NF-kappaB Signal Transduction Aorta Development Regulation Of Glycoprotein Biosynthetic Process COPII-coated ER To Golgi Transport Vesicle Regulation Of Protein Binding Centrosome Cycle Cis-Golgi Network Mitotic Spindle Assembly Microtubule-based Process Artery Development Cardiac Septum Development Intraciliary Transport Ciliary Tip Syntaxin Binding Heart Morphogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Homotetramerization	Cellular Localization Intracellular Protein Transport Establishment Of Protein Localization Golgi Organization Organelle Assembly Toll Signaling Pathway Organelle Organization Endomembrane System Organization PTB Domain Binding Nuclear Pore Central Transport Channel Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome Mitotic Centrosome Separation Protein Transport
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