OS9 and UVRAG

		OS9	UVRAG
Description		OS9 endoplasmic reticulum lectin	UV radiation resistance associated
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane	Lytic Vacuole Autophagosome Membrane Chromosome, Centromeric Region Chromosome Cytoplasm Lysosome Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Centrosome Midbody Cytoplasmic Vesicle Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle DNA-dependent Protein Kinase Complex
	Molecular Function	Protease Binding Protein Binding Carbohydrate Binding Glycosylation-dependent Protein Binding	SNARE Binding Protein Binding SH3 Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Intracellular Protein Localization Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	DNA Repair Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Autophagy DNA Damage Response Spindle Organization Chromosome Segregation Centrosome Cycle Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Cytokinesis Receptor Catabolic Process SNARE Complex Assembly Phosphatidylinositol-3-phosphate Biosynthetic Process Protein-containing Complex Organization Symbiont Entry Into Host Cell Maintenance Of Golgi Location Regulation Of Protein Serine/threonine Kinase Activity Multivesicular Body Sorting Pathway Autophagosome Maturation Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Autophagosome Maturation
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)	Asthma ( 31619474) HDL cholesterol ( 30275531) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494) Stroke ( 32693751) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 USP40 ZNF512B	10 interacting genes: CSNK1A1 ITCH MTOR NEDD4 VPS11 VPS16 VPS18 VPS33B YAP1 ZRANB1
Entrez ID		10956	7405
HPRD ID		17804	03929
Ensembl ID		ENSG00000135506	ENSG00000198382
Uniprot IDs		A0A8V8TPZ4 A0A8V8TQI8 A0A8V8TR34 Q13438	Q9P2Y5
PDB IDs		3AIH	7BL1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ossification L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Regulation Of Ossification Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Oxygen Homeostasis Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Nodal Signaling Pathway I-SMAD Binding Regulation Of MiRNA Transcription Peptide Hormone Secretion Regulation Of Macroautophagy Peptide Secretion Dioxygenase Activity Protein Hydroxylation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of Bone Mineralization 2-oxoglutarate-dependent Dioxygenase Activity Hormone Secretion Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Hormone Transport Peptide Transport Ferrous Iron Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Neuron Apoptotic Process Iron Ion Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Erythrocyte Differentiation Activin Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hypoxia Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Negative Regulation Of Biomineral Tissue Development Assembly Of Large Subunit Precursor Of Preribosome D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Monoatomic Cation Channel Activity Positive Regulation Of Protein-containing Complex Disassembly Lytic Vacuole Monocyte Activation Involved In Immune Response Positive Regulation Of Deacetylase Activity Osmosensor Activity	CORVET Complex HOPS Complex Vacuole Organization Vesicle Tethering Complex Lysosomal Transport Vacuolar Transport Endosome To Lysosome Transport Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Catabolic Process Catabolic Process Clathrin-coated Vesicle Vesicle Fusion Intracellular Protein Transport Organelle Membrane Fusion Endosome Membrane Protein Modification Process Early Endosome Organelle Fusion Regulation Of Protein Catabolic Process Lysosomal Membrane Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein-containing Complex Assembly Protein Metabolic Process Post-translational Protein Modification Cytoplasmic Vesicle Negative Regulation Of Signal Transduction Lysosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Autophagosome Endosome Organization Regulation Of Cellular Component Organization Protein Transport Protein Ubiquitination Autophagosome Assembly Autophagy Autophagosome Organization Vesicle-mediated Transport Vesicle Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Proteolysis Intracellular Transport Protein Modification By Small Protein Conjugation
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