RPP40 and POP7

Number of citations of the paper that reports this interaction (PubMedID 9630247)
33

Data Source:
HPRD (in vivo)

		RPP40	POP7
Description		ribonuclease P/MRP subunit p40	POP7 ribonuclease P/MRP subunit
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GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Cytoplasm Multimeric Ribonuclease P Complex
	Molecular Function	Ribonuclease MRP Activity RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Nucleic Acid Binding RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA 5'-leader Removal RRNA Processing TRNA Processing	TRNA 5'-leader Removal RRNA Processing RNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus
Drugs
Diseases
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Low density lipoprotein cholesterol levels ( 32154731) Medication use (thyroid preparations) ( 31015401) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Schizophrenia ( 30285260)
Interacting Genes		8 interacting genes: MEOX2 POP1 POP7 PTEN RPP14 RPP21 RPP30 RPP38	11 interacting genes: AKT1 APP C9orf72 FOXP1 HSPB1 LAGE3 RPP25 RPP25L RPP38 RPP40 SMN1
Entrez ID		10799	10248
HPRD ID		09361	09357
Ensembl ID		ENSG00000124787	ENSG00000172336
Uniprot IDs		A0A087X1N3 O75818	O75817
PDB IDs		6AHR 6AHU 6AHV	6AHR 6AHU 6CWX 6LT7
Enriched GO Terms of Interacting Partners?		Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex Ribonuclease MRP Complex TRNA Processing TRNA Metabolic Process RNA Processing Nucleolus Endoribonuclease Complex RNA Metabolic Process RNA Binding Nucleic Acid Metabolic Process RRNA Processing RRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Macromolecule Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Ribonuclease P Complex Somite Specification Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential TRNA Decay Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity	Ribonuclease MRP Complex TRNA Processing TRNA 5'-leader Removal TRNA 5'-end Processing TRNA Metabolic Process Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity RNA Processing Main Axon RNA Metabolic Process Nucleolar Ribonuclease P Complex Nucleus Regulation Of Interleukin-1 Beta Production Positive Regulation Of Endothelial Cell Migration Regulation Of Interleukin-1 Production Nucleic Acid Metabolic Process Perikaryon Cellular Response To Vascular Endothelial Growth Factor Stimulus RNA Binding Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Nitric Oxide Metabolic Process RRNA Processing Regulation Of Phosphorus Metabolic Process Postsynapse Response To Nerve Growth Factor Positive Regulation Of Cell Motility Cellular Response To Nerve Growth Factor Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Locomotion RRNA Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Ribonuclease MRP Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Macrophage Activation
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