CETN1 and POC5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CETN1	POC5
Description		centrin 1	POC5 centriolar protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Photoreceptor Connecting Cilium Cell Projection	Cytoplasm Centrosome Centriole Cytoskeleton Photoreceptor Connecting Cilium
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Centriole Replication Cellular Response To Heat Cell Division	Eye Photoreceptor Cell Development Centriole Elongation Negative Regulation Of Centriole Elongation
Pathways		Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 26961502 29615537 29273807 28892062 28552196 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Diastolic blood pressure ( 27841878 30578418 28135244) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Pulse pressure ( 30578418) Total cholesterol levels ( 29615537) Type 2 diabetes ( 29632382 30054458 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 28552196)
Interacting Genes		4 interacting genes: CCP110 POC5 PRKACA SGSM1	5 interacting genes: CALM1 CALM2 CALM3 CETN1 FAM161A
Entrez ID		1068	134359
HPRD ID		04425	08188
Ensembl ID		ENSG00000177143	ENSG00000152359
Uniprot IDs		A0A140VJG3 Q12798	Q8NA72
PDB IDs
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Cardiac Conduction Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Centrosome Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Calcium Channel Complex Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of ATP Metabolic Process Plasma Lipoprotein Particle Assembly Regulation Of Bicellular Tight Junction Assembly Cellular Response To Epinephrine Stimulus Multicellular Organismal-level Water Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Cell Communication By Electrical Coupling High-density Lipoprotein Particle Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Renal Water Homeostasis Response To Parathyroid Hormone Positive Regulation Of Gluconeogenesis Response To Glucagon Positive Regulation Of Protein Export From Nucleus Cellular Response To Cold Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Lipid Droplet Cilium Intracellular Potassium Ion Homeostasis Protein Kinase A Regulatory Subunit Binding Mitochondrial Protein Catabolic Process Response To Epinephrine CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Cell Communication Involved In Cardiac Conduction Regulation Of Cell Cycle Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of Cilium Assembly Centriole Centriole Replication Centrosome Duplication Ciliary Basal Body Organization	Spindle Microtubule Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Spindle Pole Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Centrosome Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Positive Regulation Of Sequestering Of Calcium Ion Vesicle-mediated Transport In Synapse Regulation Of Calcium-mediated Signaling
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