DCTN6 and UBXN8

		DCTN6	UBXN8
Description		dynactin subunit 6	UBX domain protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Cytoskeleton	Ubiquitin Ligase Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Dynein Complex Binding	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Binding
	Biological Process	Mitotic Spindle Organization	Single Fertilization ERAD Pathway
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Breast size ( 27182965) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		8 interacting genes: APP CDK1 ERRFI1 HSPB2 NCOA3 PMEPA1 RPSA RSPH1	7 interacting genes: AQP6 GJA8 HSD17B13 MEOX2 PGRMC2 SPCS1 TMEM14B
Entrez ID		10671	7993
HPRD ID		09907	03692
Ensembl ID		ENSG00000104671	ENSG00000104691
Uniprot IDs		O00399	A0A087WUA4 A0A087WV67 B4DKK1 O00124
PDB IDs		3TV0
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Response To Copper Ion Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Chromatin Organization Reproductive Process Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Response To Stress Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Interleukin-1 Beta Production Small Molecule Biosynthetic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Regulation Of Schwann Cell Differentiation Virus Receptor Activity Cyclin B1-CDK1 Complex Symbiont Entry Into Host Cell Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Cyclin-dependent Protein Kinase Activity Somatic Muscle Development Quinolinate Biosynthetic Process Positive Regulation Of Chronic Inflammatory Response Kynurenic Acid Biosynthetic Process
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