IGF2BP2 and MIR92A1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		IGF2BP2	MIR92A1
Description		insulin like growth factor 2 mRNA binding protein 2	microRNA 92a-1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Cytoskeleton Cytoplasmic Stress Granule	Extracellular Space Cytoplasm RISC Complex Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding N6-methyladenosine-containing RNA Reader Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Cytokine Production Regulation Of Translation Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Translation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RNA Stabilization MRNA Transport CRD-mediated MRNA Stabilization Energy Homeostasis Cold-induced Thermogenesis	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Acute Inflammatory Response Regulation Of Heart Contraction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Stress Response To Acid Chemical Vascular Endothelial Cell Response To Fluid Shear Stress Blood Vessel Diameter Maintenance Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Endothelial Cell Activation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Pathways		Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Drugs
Diseases		Type II diabetes mellitus
GWAS		A body shape index ( 34021172) Acute insulin response ( 28490609) Blood sugar levels ( 29403010) Body mass index ( 29381148 28892062) Body mass index and type 2 diabetes (pairwise) ( 33619380) Childhood onset type 2 diabetes ( 33479058) Coronary artery disease ( 29212778) Diabetes (gestational) ( 22233651) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) FEV1 ( 30804560) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Height ( 20881960 28552196 31562340 25282103) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Lymphocyte count ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Peak insulin response ( 28490609) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Thyroid stimulating hormone levels ( 32769997 30367059) Triglyceride levels ( 32203549) Two-hour glucose ( 34059833) Type 2 diabetes ( 32499647 31118516 29632382 34737425 23300278 17463248 17463249 18372903 18711366 19401414 20581827 21573907 22885922 30718926 23945395 24509480 25760438 26961502 27189021 28869590 29358691 17463246 30054458 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		75 interacting genes: CEBPA HNRNPD MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT UBXN7	76 interacting genes: ADARB1 C1QBP CELF1 CPSF1 CPSF2 CPSF6 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LRPPRC MATR3 MSI2 NOL6 NONO NUDT21 P3H1 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 QARS1 RARS1 RBM14 RBM4 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 WWP2 YBX1 YBX3
Entrez ID		10644	407048
HPRD ID		10507
Ensembl ID		ENSG00000073792	ENSG00000283705
Uniprot IDs		B3FTN5 B4DKT5 F8W930 Q9Y6M1
PDB IDs		2CQH 6ROL 7Q98 7Q99
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Translation Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Negative Regulation Of Developmental Process Regulation Of RNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Motility Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Nucleoplasm Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule MRNA 3'-UTR Binding Regulation Of Translation Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Negative Regulation Of Translation Regulation Of MRNA Stability MRNA Cleavage And Polyadenylation Specificity Factor Complex Regulation Of Primary Metabolic Process Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Paraspeckles Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation CRD-mediated MRNA Stabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-UTR Binding RNA Transport Positive Regulation Of Gene Expression
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