NPC2 and SCRN1

		NPC2	SCRN1
Description		NPC intracellular cholesterol transporter 2	secernin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Nuclear Membrane Presynapse
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Protein Binding Dipeptidase Activity Cysteine-type Exopeptidase Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Response To Virus Gene Expression Cholesterol Storage Phospholipid Transport Sterol Transport Sterol Metabolic Process Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport	Proteolysis Exocytosis Regulation Of Synaptic Vesicle Cycle
Pathways		Neutrophil degranulation LDL clearance
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Intraocular pressure ( 31959993) Refractive error ( 32231278) Soluble receptor for advanced glycation end-product levels ( 26915486)	Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	4 interacting genes: GORASP1 HGS OGT ZNF25
Entrez ID		10577	9805
HPRD ID		03008	15304
Ensembl ID		ENSG00000119655	ENSG00000136193
Uniprot IDs		A0A024R6C0 G3V3E8 P61916	A0A090N7T9 Q12765
PDB IDs		5KWY 6W5V
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Cellular Response To Ionizing Radiation BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Cellular Response To Radiation Ubiquitin-modified Histone Reader Activity Response To Radiation DNA Strand Resection Involved In Replication Fork Processing DNA Recombination Response To Stress Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Macromolecule Metabolic Process Protein K6-linked Ubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Activity Condensed Chromosome Homologous Recombination Regulation Of Protein Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Integrated Proviral Latency Adenosine Receptor Binding Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Adipose Tissue Development Mitotic G2/M Transition Checkpoint Post-translational Protein Modification DNA Repair Establishment Of Viral Latency Protein K33-linked Ubiquitination Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate	Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Negative Regulation Of Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Glycoprotein Biosynthetic Process Positive Regulation Of Transcription By Glucose Macroautophagy Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Phagocytic Vesicle Lumen Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Carbon Catabolite Regulation Of Transcription Glycoprotein Metabolic Process Glycolipid Transport Autophagy Regulation Of Transcription By Glucose Negative Regulation Of Multicellular Organismal Process Golgi Ribbon Formation Negative Regulation Of Dendrite Morphogenesis NSL Complex Regulation Of Lipid Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?