NPC2 and EOLA1

		NPC2	EOLA1
Description		NPC intracellular cholesterol transporter 2	endothelium and lymphocyte associated ASCH domain 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Mitochondrion
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Response To Virus Gene Expression Cholesterol Storage Phospholipid Transport Sterol Transport Sterol Metabolic Process Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport	Regulation Of Gene Expression Regulation Of Interleukin-6 Production
Pathways		Neutrophil degranulation LDL clearance
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Intraocular pressure ( 31959993) Refractive error ( 32231278) Soluble receptor for advanced glycation end-product levels ( 26915486)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	1 interacting genes: MT2A
Entrez ID		10577	91966
HPRD ID		03008	06625
Ensembl ID		ENSG00000119655	ENSG00000197620
Uniprot IDs		A0A024R6C0 G3V3E8 P61916	Q8TE69
PDB IDs		5KWY 6W5V	5Y7D
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Cellular Response To Ionizing Radiation BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Cellular Response To Radiation Ubiquitin-modified Histone Reader Activity Response To Radiation DNA Strand Resection Involved In Replication Fork Processing DNA Recombination Response To Stress Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Macromolecule Metabolic Process Protein K6-linked Ubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Activity Condensed Chromosome Homologous Recombination Regulation Of Protein Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Integrated Proviral Latency Adenosine Receptor Binding Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Adipose Tissue Development Mitotic G2/M Transition Checkpoint Post-translational Protein Modification DNA Repair Establishment Of Viral Latency Protein K33-linked Ubiquitination Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate	Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Response To Erythropoietin Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Glycolipid Transport Ribosomal Subunit Export From Nucleus Detoxification Of Copper Ion Copper Ion Homeostasis Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion Intracellular Copper Ion Homeostasis Structural Constituent Of Nuclear Pore Cholesterol Transfer Activity Intracellular Sterol Transport Intracellular Cholesterol Transport Intracellular Zinc Ion Homeostasis Cholesterol Efflux Response To Copper Ion Lipid Storage Intracellular Lipid Transport Response To Cadmium Ion Chemical Homeostasis Response To Zinc Ion Cholesterol Binding MRNA Export From Nucleus Cholesterol Transport Homeostatic Process RNA Export From Nucleus Intracellular Transport Nuclear Pore Phospholipid Transport Sterol Homeostasis Sterol Transport Azurophil Granule Lumen Lysosomal Lumen Carbohydrate Derivative Transport Cholesterol Homeostasis
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