PITRM1 and MFN2

		PITRM1	MFN2
Description		pitrilysin metallopeptidase 1	mitofusin 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Protein Processing	Blastocyst Formation Protein Targeting To Mitochondrion Autophagy Apoptotic Process Response To Unfolded Protein Mitochondrion Organization Mitochondrial Membrane Organization Mitochondrial Fusion Aerobic Respiration Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Camera-type Eye Morphogenesis Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Type 2 Mitophagy Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Mitochondrial protein import	PINK1-PRKN Mediated Mitophagy RHOT2 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)	Inflammatory skin disease ( 25574825) Plasma homocysteine levels ( 30339177) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494) Tuberculosis ( 29036319)
Interacting Genes			2 interacting genes: MARCHF5 PRKN
Entrez ID		10531	9927
HPRD ID		07142	08495
Ensembl ID		ENSG00000107959	ENSG00000116688
Uniprot IDs		A0A0A0MRX9 A0A7I2V397 Q5JRX3	O95140
PDB IDs		4L3T 4NGE 4RPU 6XOS 6XOT 6XOU 6XOV 6XOW	6JFK 6JFL 6JFM
Enriched GO Terms of Interacting Partners?		Protein Targeting To Mitochondrion	Protein K27-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Protein Localization To Mitochondrion Protein K63-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Regulation Of Mitochondrion Organization Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrial Outer Membrane Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Protein Polyubiquitination Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Mitochondrion Regulation Of Synaptic Vesicle Transport Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi Ubiquitin Protein Ligase Activity Zinc Ion Binding Response To Dopamine Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To L-glutamate
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