HYOU1 and DPYSL3

		HYOU1	DPYSL3
Description		hypoxia up-regulated 1	dihydropyrimidinase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Space Cytoplasm Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Projection Cell Body Synapse Exocytic Vesicle
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATP-dependent Protein Folding Chaperone	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides SH3 Domain Binding Filamin Binding Chondroitin Sulfate Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Response To Ischemia Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Pyrimidine Nucleobase Catabolic Process Nervous System Development Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Neuron Development Response To Axon Injury Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Post-bronchodilator lung function in asthma (FVC) ( 32989782)	Brain morphology (MOSTest) ( 32665545) Excessive daytime sleepiness ( 27992416) Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CDC42 CEBPA LINC01554 SEL1L	7 interacting genes: ACD DISC1 DPYSL5 OTUD6A POT1 TERF1 TNIK
Entrez ID		10525	1809
HPRD ID		03448	03104
Ensembl ID		ENSG00000149428	ENSG00000113657
Uniprot IDs		A0A384P5T6 A0A494C039 A0A8Q3SHG4 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	A0A140VK07 Q14195 Q6DEN2 Q8IXW6
PDB IDs			4BKN 4CNS 4CNT 4CNU
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Interleukin-1 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating SH3 Domain Binding Positive Regulation Of Filopodium Assembly Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Activation	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Positive Regulation Of Telomere Maintenance Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Telomere Maintenance Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Cellular Component Organization Chromosome, Telomeric Region Regulation Of Chromosome Organization Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Chromosome Organization Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding System Development Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Projection Development
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