SLC30A9 and TXNRD2

		SLC30A9	TXNRD2
Description		solute carrier family 30 member 9	thioredoxin reductase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Cytoskeleton Membrane Cytoplasmic Vesicle Mitochondrial Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Dendrite Neuronal Cell Body
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Zinc Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Nuclear Receptor Binding	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Protein Homodimerization Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Nucleotide-excision Repair Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Regulation Of Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II Transmembrane Transport Zinc Ion Transmembrane Transport	Response To Oxygen Radical Response To Oxidative Stress Response To Selenium Ion Cell Redox Homeostasis Response To Hyperoxia Cellular Oxidant Detoxification
Pathways			Detoxification of Reactive Oxygen Species
Drugs			Motexafin gadolinium
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Femur bone mineral density x serum urate levels interaction ( 34046847) Helping behaviour (self reported) ( 29324852) Opioid exposure ( 32099098)	Glaucoma ( 30054594 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary angle closure) ( 22922875) Glaucoma (primary open-angle) ( 26752265 29891935 33627673) Intraocular pressure ( 29785010 30054594 31959993) Lean body mass ( 28552196) Staphylococcus aureus infection ( 24847357)
Interacting Genes		4 interacting genes: CTNNB1 ESR1 NCOA2 UBC	8 interacting genes: BCAS2 CFTR GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 TADA3
Entrez ID		10463	10587
HPRD ID		06858	18519
Ensembl ID		ENSG00000014824	ENSG00000184470
Uniprot IDs		A0A0S2Z512 A0A0S2Z514 Q6PML9	A0A096LPD9 E7EWK1 Q9NNW7
PDB IDs		2ENK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Plasma Membrane Repair Muscle Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Staurosporine Response To Lipid Transcription Regulator Complex Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process DNA-templated Transcription Mesenchymal Stem Cell Differentiation Oviduct Development Nuclear Estrogen Receptor Binding Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Genitalia Development Stem Cell Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Transcription Corepressor Binding Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Regulation Of Morphogenesis Of A Branching Structure Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Response To Estradiol Renal Outer Medulla Development Transcription Coregulator Binding Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Branching Morphogenesis Of An Epithelial Tube Regulation Of Morphogenesis Of An Epithelium Protein-containing Complex Nuclear Receptor Binding Glial Cell-neuron Signaling Regulation Of Fibroblast Proliferation Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation RNA Polymerase II Transcription Regulator Complex	Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Coactivator Activity Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Binding Circadian Behavior Rhythmic Behavior Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleotide-excision Repair Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Nucleoplasm Positive Regulation Of Biosynthetic Process Positive Regulation Of Anion Channel Activity Spindle Assembly Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Monoatomic Anion Transport Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Enamel Mineralization Circadian Rhythm Mitotic Spindle Transepithelial Water Transport Hormone-mediated Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Response To Thyroglobulin Triiodothyronine Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tooth Mineralization Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Proteasome-activating Activity Spindle Organization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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