SYCP2 and HORMAD2

Number of citations of the paper that reports this interaction (PubMedID 30657449)
107

Data Source:
BioGRID (two hybrid, pull down)

		SYCP2	HORMAD2
Description		synaptonemal complex protein 2	HORMA domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Synaptonemal Complex Lateral Element Nucleus Chromosome	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Centrosome Cytosol
	Molecular Function	DNA Binding	Protein Binding
	Biological Process	Apoptotic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Female Meiotic Nuclear Division Fertilization Animal Organ Morphogenesis Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Male Genitalia Morphogenesis Negative Regulation Of Developmental Process Cell Division Meiotic Cell Cycle Negative Regulation Of Reproductive Process	Meiotic Sister Chromatid Cohesion Meiotic Cell Cycle
Pathways		Meiotic synapsis
Drugs
Diseases
GWAS		Delirium ( 29631748)	Albumin-globulin ratio ( 29403010) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Behcet's disease ( 33393726) Cataracts ( 34127677) Creatine kinase levels ( 29403010) Crohn's disease ( 28067908) Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) IgA nephropathy ( 26028593 32912934 25305756) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Medication use (thyroid preparations) ( 31015401) Moyamoya disease ( 29273593) Nephropathy ( 21399633) Neutrophil percentage of white cells ( 27863252 32888494) Non-albumin protein levels ( 29403010) Optic cup area ( 31798171) Optic disc area ( 25631615) Tonsillectomy ( 27941131) Type 1 diabetes ( 30572963) Type 2 diabetes ( 30054458) Vertical cup-disc ratio ( 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		3 interacting genes: HORMAD2 SRPK2 SYCP3	2 interacting genes: NSD2 SYCP2
Entrez ID		10388	150280
HPRD ID		06822	13668
Ensembl ID		ENSG00000196074	ENSG00000176635
Uniprot IDs		Q9BX26	Q8N7B1
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptonemal Complex Chromosome Meiotic Cell Cycle Nuclear Speck Organization Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination R-loop Processing Meiotic Sister Chromatid Cohesion	Histone H3K36 Trimethyltransferase Activity Positive Regulation Of Isotype Switching To IgA Isotypes Atrial Septum Secundum Morphogenesis Atrial Septum Primum Morphogenesis Histone H3K36 Dimethyltransferase Activity Male Genitalia Morphogenesis Histone H4K20 Methyltransferase Activity Histone H3K36 Methyltransferase Activity Membranous Septum Morphogenesis Chromosome Genitalia Morphogenesis Lateral Element Histone H3 Methyltransferase Activity Atrial Septum Morphogenesis Synaptonemal Complex Condensed Chromosome, Centromeric Region Programmed Cell Death Involved In Cell Development Synaptonemal Complex Assembly Synaptonemal Complex Organization Ectopic Germ Cell Programmed Cell Death Female Meiotic Nuclear Division Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Histone Methyltransferase Activity Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Male Meiotic Nuclear Division Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of Immunoglobulin Production Anatomical Structure Morphogenesis Negative Regulation Of Reproductive Process Positive Regulation Of DNA Recombination Cardiac Septum Morphogenesis Bone Development Meiotic Nuclear Division Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Activation Nuclear Division
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