ABCA8 and BACE2

		ABCA8	BACE2
Description		ATP binding cassette subfamily A member 8	beta-secretase 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Nucleotide Binding Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Sphingomyelin Biosynthetic Process Xenobiotic Transmembrane Transport Lipid Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Efflux Cholesterol Transport Cholesterol Efflux Xenobiotic Transport Transmembrane Transport	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process
Pathways		ABC-family proteins mediated transport
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26582766) Coronary artery disease ( 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899 32203549) High density lipoprotein cholesterol levels ( 33339817) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol ( 25961943) Phosphorus levels ( 29403010) Soluble VCAM-1 levels ( 31217265) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)
Interacting Genes			5 interacting genes: APP GGA1 GGA2 PCM1 SNRNP70
Entrez ID		10351	25825
HPRD ID		09790	05744
Ensembl ID		ENSG00000141338	ENSG00000182240
Uniprot IDs		A0A0A0MSU4 O94911	Q9Y5Z0
PDB IDs			2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N
Enriched GO Terms of Interacting Partners?		Membrane Protein Ectodomain Proteolysis Melanosome Membrane Regulation Of Glycoprotein Biosynthetic Process Melanosome Organization Amyloid-beta Metabolic Process Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Aspartic-type Endopeptidase Activity Pigment Granule Organization Regulation Of Amyloid Precursor Protein Biosynthetic Process Membrane Protein Proteolysis Melanosome Hormone Metabolic Process Carbohydrate Homeostasis Protein Processing Trans-Golgi Network Glucose Homeostasis	Regulation Of Protein Folding
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