CDKN2D and ZNF396

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDKN2D	ZNF396
Description		cyclin dependent kinase inhibitor 2D	zinc finger protein 396
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cyclin D2-CDK4 Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Response To UV Negative Regulation Of Cell Growth Response To Retinoic Acid Response To Vitamin D Autophagic Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Parasitemia in Tripanosoma cruzi seropositivity ( 24324551) Parkinson's disease ( 26227905)
Interacting Genes		63 interacting genes: APP BRCA1 BTG1 C1orf94 CCND3 CDK4 CDK6 CFAP90 CGGBP1 CTBP1 DDIT4L DMRTB1 DYNLT2B EIF4G1 FAM228A FAM86C1P FHL3 GATAD2B GLYR1 GORASP2 GSC2 HSD17B14 IKZF3 INCA1 KRT75 LNX1 LONRF1 LSM3 MEI4 MEOX2 MSS51 MTF2 NDUFB7 NIF3L1 NME4 NMI NR4A1 NR4A2 NR4A3 PICK1 PRDX5 PRIMPOL PSMA1 QKI REL RUFY4 SAXO1 SDCBP SH3GLB1 SH3GLB2 TBC1D17 TEX11 THAP1 TSG101 TSGA10IP UQCC2 VGLL1 YPEL3 ZBTB32 ZNF396 ZNF620 ZNF688 ZNF774	8 interacting genes: CDKN2D NFE2L2 PROSER3 SPSB3 ZNF397 ZSCAN1 ZSCAN21 ZSCAN32
Entrez ID		1032	252884
HPRD ID		02957	18334
Ensembl ID		ENSG00000129355	ENSG00000186496
Uniprot IDs		P55273	Q96N95
PDB IDs		1BD8 1BI8
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Corticotropin-releasing Hormone Stimulus Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Organelle Assembly Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromatin Cyclin-dependent Protein Serine/threonine Kinase Activity Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Extracellular Exosome Assembly Negative Regulation Of Metabolic Process Cyclin Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Type I Interferon Production DNA-binding Transcription Factor Activity Nuclear Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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