SIGMAR1 and NFX1

		SIGMAR1	NFX1
Description		sigma non-opioid intracellular receptor 1	nuclear transcription factor, X-box binding 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Postsynaptic Density Membrane Growth Cone Cytoplasmic Vesicle Cell Projection Synapse Postsynaptic Membrane Anchoring Junction Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane
	Molecular Function	G Protein-coupled Opioid Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Transport Nervous System Development G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization Regulation Of Postsynapse Assembly	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Protein Ubiquitination Negative Regulation Of MHC Class II Biosynthetic Process Protein Autoubiquitination
Pathways		Potential therapeutics for SARS
Drugs		Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Naltrexone Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Pimavanserin Noscapine Captodiame Pentoxyverine
Diseases
GWAS			Fasting glucose ( 34059833)
Interacting Genes		5 interacting genes: ANK2 GHSR ITPR3 PDZD11 SRI	5 interacting genes: ELAVL4 MAML3 UBC UBE2N UBE3A
Entrez ID		10280	4799
HPRD ID		03580	11936
Ensembl ID		ENSG00000147955	ENSG00000086102
Uniprot IDs		A0A7P0T9D5 A0A7P0Z4C2 B4DR71 Q99720	Q12986
PDB IDs		5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Polyubiquitination Post-translational Protein Modification Ligase Inhibitor Activity Negative Regulation Of TORC1 Signaling Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of TOR Signaling Pre-mRNA Intronic Pyrimidine-rich Binding Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution UBC13-MMS2 Complex Regulation Of Golgi Lumen Acidification Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus Growth Cone Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of TOR Signaling Positive Regulation Of Cellular PH Reduction Mitochondrial Depolarization Oncogene-induced Cell Senescence Negative Regulation Of Immature T Cell Proliferation Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process RNA Binding Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Lysosome G Protein-coupled Opioid Receptor Activity Myosin Phosphatase Regulator Activity Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Myeloid Cell Apoptotic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?