STAG1 and MSL2

		STAG1	MSL2
Description		STAG1 cohesin complex component	MSL complex subunit 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol Cilium Cohesin Complex Nuclear Matrix Nuclear Body Mitotic Cohesin Complex Mitotic Spindle Pole	Chromatin Nucleus Nucleoplasm Chromosome MSL Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Promoter-enhancer Loop Anchoring Activity Histone H2B Ubiquitin Ligase Activity
	Biological Process	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Mitotic Spindle Assembly	Chromatin Organization Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	HATs acetylate histones
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Central corneal thickness ( 32528159 29760442 31798171) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) Height ( 25282103) Intraocular pressure ( 29617998) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 31194737 33830993) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Plateletcrit ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Waist circumference adjusted for body mass index ( 34021172)	Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Blood urea nitrogen levels ( 31152163) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778 33020668) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31217584) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 29483656 28991256 25056061) Serum alkaline phosphatase levels ( 33339817 33547301) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		7 interacting genes: CALM1 DSCAM RAD21 SMAD2 SMAD9 STAG2 WFDC5	14 interacting genes: APOBEC3B H2AC18 H2AC20 H2BC21 H3C14 H4C1 PAF1 TP53 TRIM8 UBE2D3 VHL YWHAE YWHAG YWHAZ
Entrez ID		10274	55167
HPRD ID		05076	08550
Ensembl ID		ENSG00000118007	ENSG00000174579
Uniprot IDs		Q8WVM7	Q9HCI7
PDB IDs		5QSM 5QSN 5QSO 5QSP 5QSQ 5QSR 5QSS 5QST 5QSU 5QSV 5QSW 5QSX 5QSY 5QSZ 6QB5 6R7O 6RRC 6RRK 6WG3 7W1M	4B7Y 4B86
Enriched GO Terms of Interacting Partners?		Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Heteromeric SMAD Protein Complex SMAD Protein Complex Establishment Of Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion I-SMAD Binding Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion SMAD Protein Signal Transduction Calcium Channel Complex Spindle Pole Chromosome, Centromeric Region Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum DGDP Biosynthetic Process GDP Biosynthetic Process Organ Growth Condensed Nuclear Chromosome Calcitriol Binding Lithocholic Acid Binding Histone H2B Ubiquitin Ligase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Homomeric SMAD Protein Complex Negative Regulation Of Phosphate Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Intracellular Signal Transduction Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Glycoprotein Transport Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization	Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Sequestering Activity Chromatin Remodeling Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Extracellular Exosome Chromosome Negative Regulation Of Metabolic Process Negative Regulation Of TORC1 Signaling Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of TOR Signaling Negative Regulation Of RNA Metabolic Process Protein Polyubiquitination Regulation Of TORC1 Signaling Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Protein Ubiquitination Protein Localization To Organelle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleosome Organization Protein Modification By Small Protein Conjugation Protein K6-linked Ubiquitination Regulation Of Protein Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Response To Stress Negative Regulation Of DNA-templated Transcription Protein Localization To Nucleus Cellular Response To Starvation Post-translational Protein Modification Protein K11-linked Ubiquitination Protein-DNA Complex Assembly Chromatin Binding Proteasomal Protein Catabolic Process Protein Targeting Negative Regulation Of Signal Transduction Regulation Of Protein Localization Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition
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