MPHOSPH9 and KNTC1

Data Source: HiPPIP (Novel)

		MPHOSPH9	KNTC1
Name		M-phase phosphoprotein 9	kinetochore associated 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Centrosome Centriole Cytoskeleton Membrane	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton RZZ Complex
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Cilium Assembly	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Exit From Mitosis Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly
Pathways		None	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		A body shape index ( 34021172 ) Albumin-globulin ratio ( 29403010 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Educational attainment ( 25201988 ) Hip circumference adjusted for BMI ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Multiple sclerosis ( 19525953 ) Plasma anti-thyroglobulin levels ( 29678681 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 ) Schizophrenia ( 23974872 30285260 29483656 28991256 25056061 ) Tourette syndrome ( 30818990 ) Type 2 diabetes ( 30297969 29632382 24509480 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Venous thromboembolism ( 31420334 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	A body shape index ( 34021172 ) Adult body size ( 32376654 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 28892062 ) Hand grip strength ( 29691431 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Menopause (age at onset) ( 26414677 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Walking pace ( 33128006 )
Novel Interactors		15 novel interactors: ACACA ALPP ANXA11 ARF5 ATP6V0A2 CABP1 GSK3A HCAR3 KNTC1 MLEC MRPL19 RAB35 SNRNP35 SRSF9 TRA2A	1 novel interactors: MPHOSPH9
Interacting Genes		3 interacting genes: SVIL YWHAG YWHAZ	3 interacting genes: CEBPA PIAS4 ZWILCH
Entrez ID		10198	9735
HPRD ID		12022	09561
Ensembl ID		ENSG00000051825	ENSG00000184445
Uniprot IDs		Q99550	P50748
PDB IDs		Not available	7QPG
GO Terms Enriched among Interactors		None	Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Limb Epidermis Development CHOP-C/EBP Complex Steroid Metabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Keratinocyte Apoptotic Process RZZ Complex Urea Metabolic Process HMG Box Domain Binding Response To Phenylpropanoid Negative Regulation Of Cell Cycle Urea Cycle STAT Family Protein Binding Fat Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization To Chromatin Regulation Of Keratinocyte Apoptotic Process Vitamin D Metabolic Process SUMO Ligase Activity Negative Regulation Of Protein Localization To Chromatin Transferase Complex Positive Regulation Of Protein Sumoylation Protein Localization To Kinetochore Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development