RCL1 and PUM3

		RCL1	PUM3
Description		RNA terminal phosphate cyclase like 1	pumilio RNA binding family member 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Lumen Small-subunit Processome	Nucleus Nucleoplasm Chromosome Nucleolus Endoplasmic Reticulum
	Molecular Function	Catalytic Activity RNA Endonuclease Activity Protein Binding	DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Regulation Of Translation Regulation Of Protein ADP-ribosylation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 19862010 28017375 27863252 23263863 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978 29403010 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 29403010 31194788 27863252 26805783 24026423 23263863 33545615 22139419 20139978) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494 28017375 29403010 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)	Depression ( 29700475) Smoking initiation ( 33082346) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		1 interacting genes: GOLGA2	5 interacting genes: APP CALM1 CEBPA HPS6 ITGB1BP2
Entrez ID		10171	9933
HPRD ID		10189	08822
Ensembl ID		ENSG00000120158	ENSG00000080608
Uniprot IDs		Q5VZU3 Q9Y2P8	Q15397
PDB IDs		7MQ8 7MQ9 7MQA	4WZR 4WZW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Glycosylation Golgi Cis Cisterna Regulation Of Protein Glycosylation Golgi Ribbon Formation Importin-alpha Family Protein Binding Golgi Disassembly Regulation Of Protein ADP-ribosylation Asymmetric Cell Division Meiotic Spindle Assembly Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Glycoprotein Biosynthetic Process Meiotic Spindle Organization Negative Regulation Of Protein Binding Microtubule Nucleation Regulation Of Glycoprotein Biosynthetic Process Syntaxin Binding COPII-coated ER To Golgi Transport Vesicle Regulation Of Protein Binding Centrosome Cycle Cis-Golgi Network Mitotic Spindle Assembly Protein Homotetramerization Golgi Cisterna Membrane Regulation Of Protein Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Organelle Disassembly Microtubule Organizing Center Organization Mitotic Spindle Organization Spindle Assembly Protein Tetramerization Negative Regulation Of Autophagy	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Dendritic Shaft Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Metal Ion Chemical Homeostasis Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Membrane Potential Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Response To Peptide Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Response To Cytokine Regulation Of Inflammatory Response Regulation Of Calcium-mediated Signaling Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Protein Heterodimerization Activity Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport
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