RCL1

Description		RNA terminal phosphate cyclase like 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Lumen Small-subunit Processome
	Molecular Function	Catalytic Activity RNA Endonuclease Activity Protein Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 19862010 28017375 27863252 23263863 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978 29403010 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 29403010 31194788 27863252 26805783 24026423 23263863 33545615 22139419 20139978) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494 28017375 29403010 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Novel Interacting Genes		1 novel interacting genes: PUM3
Interacting Genes		1 interacting genes: GOLGA2
Entrez ID		10171
HPRD ID		10189
Ensembl ID		ENSG00000120158
Uniprot IDs		Q5VZU3 Q9Y2P8
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Glycosylation Golgi Cis Cisterna Regulation Of Protein Glycosylation Golgi Ribbon Formation Importin-alpha Family Protein Binding Golgi Disassembly Regulation Of Protein ADP-ribosylation Asymmetric Cell Division Meiotic Spindle Assembly Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Glycoprotein Biosynthetic Process Meiotic Spindle Organization Negative Regulation Of Protein Binding Microtubule Nucleation Regulation Of Glycoprotein Biosynthetic Process Syntaxin Binding COPII-coated ER To Golgi Transport Vesicle Regulation Of Protein Binding Centrosome Cycle Cis-Golgi Network Mitotic Spindle Assembly Protein Homotetramerization Golgi Cisterna Membrane Regulation Of Protein Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Organelle Disassembly Microtubule Organizing Center Organization Mitotic Spindle Organization Spindle Assembly Protein Tetramerization Negative Regulation Of Autophagy
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