CDK2 and CEBPA

Number of citations of the paper that reports this interaction (PubMedID 34189442)
73

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		CDK2	CEBPA
Description		cyclin dependent kinase 2	CCAAT enhancer binding protein alpha
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Condensed Chromosome X Chromosome Y Chromosome Male Germ Cell Nucleus Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cajal Body Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Nuclear Matrix Protein-containing Complex Rb-E2F Complex CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex C/EBP Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Domain Specific Binding Cyclin Binding Histone Kinase Activity Metal Ion Binding Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Domain Specific Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication DNA Repair Chromatin Remodeling DNA-templated Transcription Protein Phosphorylation Potassium Ion Transport DNA Damage Response Centriole Replication Signal Transduction Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Peptidyl-serine Phosphorylation Positive Regulation Of Heterochromatin Formation Mitotic G1 DNA Damage Checkpoint Signaling Protection From Non-homologous End Joining At Telomere Positive Regulation Of DNA-templated DNA Replication Initiation Telomere Maintenance In Response To DNA Damage Post-translational Protein Modification Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Centrosome Duplication Cell Division Meiotic Cell Cycle Cellular Response To Nitric Oxide Cellular Senescence Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Urea Cycle Negative Regulation Of Transcription By RNA Polymerase II Liver Development Embryonic Placenta Development Epithelial Cell Maturation Osteoblast Development Generation Of Precursor Metabolites And Energy DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase I Acute-phase Response Mitochondrion Organization Notch Signaling Pathway Response To Nutrient Memory Cholesterol Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Cell Differentiation Macrophage Differentiation Lung Development Granulocyte Differentiation Animal Organ Regeneration Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Vitamin B2 Regulation Of Cell Population Proliferation Glucose Homeostasis Positive Regulation Of Macrophage Activation Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Positive Regulation Of Inflammatory Response White Fat Cell Differentiation Brown Fat Cell Differentiation Regulation Of Cell Cycle Lipid Homeostasis Interleukin-6-mediated Signaling Pathway White Fat Cell Proliferation Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Response To Phenylpropanoid Energy Homeostasis Integrated Stress Response Signaling Negative Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation
Pathways		G0 and Early G1 Telomere Extension By Telomerase Activation of ATR in response to replication stress Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle Meiotic recombination Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide Staurosporine Indirubin-3'-monoxime 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine Olomoucine 4-[(4-Imidazo[1,2-a]Pyridin-3-Ylpyrimidin-2-Yl)Amino]Benzenesulfonamide 2-Amino-6-Chloropyrazine 6-O-Cyclohexylmethyl Guanine N-[4-(2-Methylimidazo[1,2-a]Pyridin-3-Yl)-2-Pyrimidinyl]Acetamide 1-Amino-6-Cyclohex-3-Enylmethyloxypurine N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide Purvalanol [4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine (5R)-5-{[(2-Amino-3H-purin-6-yl)oxy]methyl}-2-pyrrolidinone 4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamine Hymenialdisine (5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amine 4-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamide 4-(2,5-Dichloro-Thiophen-3-Yl)-Pyrimidin-2-Ylamine 4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline SU9516 3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole Alvocidib (2E,3S)-3-hydroxy-5'-[(4-hydroxypiperidin-1-yl)sulfonyl]-3-methyl-1,3-dihydro-2,3'-biindol-2'(1'H)-one 1-[(2-Amino-6,9-Dihydro-1h-Purin-6-Yl)Oxy]-3-Methyl-2-Butanol 4-((3r,4s,5r)-4-Amino-3,5-Dihydroxy-Hex-1-Ynyl)-5-Fluoro-3-[1-(3-Methoxy-1h-Pyrrol-2-Yl)-Meth-(Z)-Ylidene]-1,3-Dihydro-Indol-2-One Lysine Nz-Carboxylic Acid [2-Amino-6-(2,6-Difluoro-Benzoyl)-Imidazo[1,2-a]Pyridin-3-Yl]-Phenyl-Methanone N'-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-2-pyrimidinyl]-N-hydroxyimidoformamide N'-(Pyrrolidino[2,1-B]Isoindolin-4-On-8-Yl)-N-(Pyridin-2-Yl)Urea 2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine 4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol 3-[4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE OLOMOUCINE II TRIAZOLOPYRIMIDINE Seliciclib Bosutinib 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA (5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE (2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamide 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE 3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE 5-Bromoindirubin (2S)-1-{4-[(4-Anilino-5-bromo-2-pyrimidinyl)amino]phenoxy}-3-(dimethylamino)-2-propanol (2R)-1-{4-[(4-Anilino-5-bromo-2-pyrimidinyl)amino]phenoxy}-3-(dimethylamino)-2-propanol (5E)-2-Amino-5-(2-pyridinylmethylene)-1,3-thiazol-4(5H)-one 4-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID 4-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDE N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE CAN-508 (2R)-1-[4-({4-[(2,5-Dichlorophenyl)amino]-2-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanol (2S)-1-[4-({6-[(2,6-Difluorophenyl)amino]-4-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanol (2S)-1-[4-({4-[(2,5-Dichlorophenyl)amino]-2-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanol (2R)-1-[4-({6-[(2,6-Difluorophenyl)amino]-4-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanol N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE 4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID (2S)-1-(Dimethylamino)-3-(4-{[4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenoxy)-2-propanol N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE RO-4584820 N-Methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide N-methyl-{4-[2-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)hydrazino]phenyl}methanesulfonamide 3-{[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3-dihydro-2H-indol-2-one 4-{[(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide 3-{[4-([amino(imino)methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1H-indole 5-hydroxynaphthalene-1-sulfonamide N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide N-phenyl-1H-pyrazole-3-carboxamide 4-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide (4E)-N-(4-fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamide {[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide 5-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile 5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 4-{[(2,6-difluorophenyl)carbonyl]amino}-N-[(3S)-piperidin-3-yl]-1H-pyrazole-3-carboxamide AT-7519 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM 4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amine 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid 6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 3-bromo-5-phenyl-N-(pyrimidin-5-ylmethyl)pyrazolo[1,5-a]pyridin-7-amine 3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine 3-cyclopropyl-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE 4-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDE N-(5-Isopropyl-thiazol-2-YL)-2-pyridin-3-YL-acetamide Variolin B N(6)-dimethylallyladenine Trilaciclib
Diseases			Acute myeloid leukemia (AML)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 21804548 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Gastroesophageal reflux disease ( 31527586) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 30423114) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Asthma ( 34103634 31959851 30929738) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Basophil count ( 28031487) Birth weight ( 31043758) Hip index ( 34021172) Mastocytosis (KIT D816V positive) ( 33421400) Red blood cell count ( 29403010) Visceral adipose tissue volume ( 34128465) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count (basophil) ( 29403010 28158719)
Interacting Genes		148 interacting genes: ACKR4 ACTL6A ARID4A ASB7 BARD1 BCL2 BRCA1 BRCA2 BTBD2 CBY2 CCNA1 CCNA2 CCNB2 CCNB3 CCNE1 CCNE2 CCNH CCNK CCP110 CDC25A CDC25B CDC25C CDC37 CDC5L CDC6 CDC7 CDK20 CDK2AP1 CDK7 CDKN1A CDKN1B CDKN3 CDT1 CDX2 CEBPA CHAF1A CHAF1B CINP CKS1B CNOT7 COIL CTNNB1 DBF4 DTL E2F1 EGLN2 EP300 ESR1 FBXO32 FBXW2 FEN1 FOXM1 FZR1 GATA3 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HIRA ID2 ID3 IKBKG IL15RA INCA1 ING5 IQGAP1 KAT2A KAT2B KCTD13 KIF26B KLF10 KLHL6 LATS2 LNX2 LYN MAPRE2 MAPT MARCKS MCM2 MCM3 MCM4 MLST8 MNDA MRE11 MTRFR MYBL2 MYOD1 NCOR2 NFYA NPDC1 NPM1 ORC1 ORC2 PCGF2 PCNA PGR PHLDA3 PIN1 PML POLA1 POLD1 POLD2 POLL PPM1B PPP2CA PRC1 PRKAR1A PRKCH PTHLH PTMA PTPN2 RANGAP1 RB1 RBL1 RBL2 RBM4 RLIM RNF148 RPS3 RRN3 RUNX1 SCN5A SIRT1 SIRT2 SKP2 SLBP SMAD2 SMAD3 SP1 SPDYA SUMO2 TFDP1 TP53 TP73 TRIM10 TSPYL2 TTK UBE2A UBE2H UBE2T UBTF UHRF2 WEE1 XRCC6 ZBTB20	831 interacting genes: AARS1 ABCE1 ABCF1 ACLY ACSL1 ACTG1 ACTN1 ACTN4 ACTR1A ACTR2 ADAR AHCY AHSA1 AIMP2 AIP AK6 ALDOA ALKBH5 ALYREF ANAPC7 ANLN ANXA5 ANXA6 AP1B1 AP2B1 AP2M1 APEH APEX1 AR ARHGAP15 ARHGDIA ARHGDIB ARHGEF2 ARL6IP4 ARPC1B ARPC3 ASNS ATF2 ATF4 ATF5 ATIC ATP1A1 ATP2A2 ATXN2 ATXN2L AURKA BAG1 BAG6 BANF1 BATF BATF2 BATF3 BCAP31 BCAT1 BCL2L2 BCLAF1 BIN2 BLMH BTF3 BTF3L4 BUB3 BUD23 BUD31 BZW1 BZW2 C11orf58 C19orf53 C1QBP C2orf49 CAB39 CACYBP CAD CALU CAMK2G CAND1 CAP1 CAPG CAPRIN1 CAPZA1 CAPZB CC2D1A CCAR2 CCDC12 CCDC7 CCNB1 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 CCZ1 CDC42 CDK1 CDK13 CDK2 CDK4 CDK7 CDK8 CDK9 CDKN1A CDKN2AIP CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CELF1 CELF2 CEP170 CGGBP1 CHD4 CHD8 CHEK1 CHMP4B CHMP5 CHTOP CIAPIN1 CIRBP CIT CKAP5 CLASP1 CLIC1 CLINT1 CLTA CLTB CLTC CMSS1 CNOT1 COPS3 COPS4 COPS5 CORO1A CORO1C CPNE1 CPSF6 CPSF7 CREBBP CRIPT CSDE1 CSNK1A1 CSNK2A1 CSNK2A2 CSTF3 CTNNB1 CTPS1 CUL1 CUL3 CUTA CZIB DARS1 DAZAP1 DBP DCD DCPS DCXR DDX1 DDX17 DDX19B DDX23 DDX39A DDX3X DDX41 DDX49 DDX5 DDX55 DDX6 DEK DHX15 DIDO1 DIMT1 DNAJB1 DNAJC8 DNAJC9 DNM2 DNMT1 DOCK2 DOCK8 DPP3 DRG1 DTYMK DYNC1H1 DYNC1LI1 DYNLRB1 ECPAS EDC4 EDF1 EEF1A1 EEF1B2 EEF1D EEF1E1 EEF1G EEF2 EEFSEC EIF1 EIF2A EIF2S1 EIF2S2 EIF2S3 EIF4A1 EIF4A3 EIF4B EIF4E EIF4G2 EIF4H EIF5 EIF5B ELAVL1 ELMO1 ELOB ELOC EMG1 ENY2 EP300 EP400 EPRS1 ERGIC3 ERP29 ESR1 ETF1 ETV6 EVL EWSR1 EXOSC10 EZR FAM120A FAM136A FAM32A FAM76B FAM98B FANCI FARSB FASN FDPS FEN1 FIP1L1 FKBP3 FKBP4 FKBP5 FLNA FLYWCH2 FNBP1 FOS FOSL1 FOXK1 FRG1 FUBP1 FUBP3 FUS G3BP1 G3BP2 GABARAPL2 GABPA GABPB1 GAPDH GARS1 GATA2 GATAD2A GBE1 GDI2 GET4 GLO1 GLRX3 GLTP GMFG GMNN GMPS GOPC GRB2 GRWD1 GSK3B GSN GSPT1 GSTP1 GTF2F1 GTF2F2 GTF2I GTPBP1 GTSF1 H1-2 H1-5 H2AC20 H2BC15 H3-3A H4C1 HADHA HADHB HAT1 HCFC1 HDAC1 HDAC2 HDGF HDLBP HEATR3 HEBP2 HELLS HEXIM1 HLTF HMGA1 HMGB1 HMGB2 HMGB3 HMGCS1 HMGN1 HMGN2 HMGN4 HMMR HNF1A HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPAB HNRNPD HNRNPDL HNRNPK HNRNPL HNRNPLL HNRNPR HNRNPU HNRNPUL1 HOMER3 HPCAL1 HPRT1 HSD17B4 HSPA1B HSPA4 HSPH1 HYOU1 IARS1 IFI16 IGF2BP1 IGF2BP2 IGF2BP3 IK ILF2 ILF3 ILK IMPDH2 INPP5D INTS12 IPO11 IPO7 IQGAP1 IRF2BP1 IRF2BP2 ITPA KARS1 KAT2A KAT8 KCNAB2 KHDRBS1 KHSRP KIF11 KIF2A KIF2C KIF4A KIF5B KIFC1 KNTC1 KPNB1 LARP1 LARS1 LASP1 LCP1 LDHA LDHB LIG1 LIMD2 LMAN1 LRWD1 LSM12 LSM14A LSM14B LSM2 LSM5 LSM6 LSM7 MAGOHB MAP2K7 MAP4 MAP7D1 MAPK1 MAPK8 MARS1 MAT2A MAT2B MBNL1 MCM4 MCM5 MCM7 MCTS1 MED1 MED10 MED12 MED14 MED15 MED16 MED17 MED21 MED22 MED23 MED24 MED27 MED28 MED29 MED4 MED6 MED8 METAP2 MIF MITD1 MKI67 MLKL MNDA MORC2 MORF4L1 MPO MRE11 MRTO4 MSH2 MSH6 MSN MSX2 MTA2 MTHFD1 MTPN MTREX MVK MYC MYCBP2 MYL6 MZT2B NAA10 NAA15 NAA50 NAE1 NARS1 NCAPD3 NCAPG2 NCF1 NCOA6 NEDD1 NEK6 NELFA NELFB NELFE NFYA NHERF1 NIFK NME2 NOC4L NOLC1 NONO NOP14 NOP2 NOP58 NOSIP NPEPPS NR3C1 NSFL1C NSUN2 NSUN5 NTPCR NUCKS1 NUDC NUDT16L1 NUDT21 NUP153 NUP50 NUP93 NUSAP1 NUTF2 NXF1 OLA1 ORC3 ORC5 ORC6 OTUB1 PA2G4 PABPC1 PABPC4 PAF1 PAICS PAK2 PARP1 PCBP2 PCLAF PCM1 PCMT1 PCNP PDAP1 PDCD5 PDCD6 PDIA3 PDIA4 PDS5A PDS5B PEBP1 PES1 PFDN1 PFDN2 PFDN5 PFDN6 PFKL PFKM PGAM1 PGK1 PHF6 PHGDH PIAS1 PIN1 PIN4 PKM PLIN3 PLK1 PLRG1 PNP POLDIP3 POLR1D PPA1 PPAT PPIB PPIH PPIL2 PPME1 PPP2CA PPP3CA PPP4R2 PPP4R3A PPP5C PQBP1 PRAM1 PRC1 PRDX1 PRKDC PRKRIP1 PRMT1 PRPF19 PRPF3 PRPF31 PRPF38B PRPF39 PRPF4 PRPF6 PRPS1 PRRC2A PRRC2C PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB7 PSMC1 PSMC3 PSMC4 PSMC6 PSMD10 PSMD11 PSMD12 PSMD14 PSMD6 PSMD7 PSME1 PSME2 PSME3 PSMG1 PSPC1 PTBP1 PUF60 PUM3 PURB PYGL QKI RAB10 RAB2A RAB3GAP2 RAC1 RAD23A RAD23B RAD50 RAE1 RANBP1 RANBP2 RARA RARB RARS1 RASGRF1 RASGRP2 RAVER1 RB1 RBL1 RBM14 RBM15 RBM17 RBM22 RBM26 RBM27 RBM28 RBM3 RBM33 RBM39 RBMX RCC1 RCC2 RCOR1 RECQL RFC1 RFC2 RFC3 RFC4 RFC5 RHOA RHOG RNGTT RNH1 RPA1 RPA2 RPL9 RPP30 RPS28 RPS29 RRM1 RSL1D1 RTCB RTRAF RUNX1 RUVBL2 S100A11 S100P SAE1 SAFB SAFB2 SAR1A SARNP SART1 SBDS SCAF4 SCP2 SEH1L SEPTIN14 SEPTIN2 SEPTIN6 SEPTIN9 SERF2 SF1 SF3A1 SF3A2 SF3B6 SFPQ SIN3A SKP2 SLAIN2 SLBP SLC25A5 SLC3A2 SLFN11 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCC2 SMARCD2 SMARCE1 SMC1A SMC2 SMC3 SMC4 SMCHD1 SMNDC1 SMS SMU1 SND1 SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNW1 SNX9 SORD SOX10 SOX8 SPAST SPI1 SPR SRA1 SRM SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRRM2 SRSF7 SSB SSBP1 SSRP1 STAT1 STAU1 STEEP1 STK10 STMN1 STRAP SUB1 SUGP1 SUGP2 SUGT1 SUMO1 SUMO2 SUMO3 SURF4 SYK SYNCRIP TADA3 TALDO1 TAOK3 TARS1 TBCA TBL1XR1 TCEA1 TCERG1 TCP1 TEX30 THAP11 THOC2 THRAP3 THYN1 TIAL1 TIPRL TKT TLN1 TM9SF3 TMA16 TMA7 TMED10 TMPO TNPO2 TNPO3 TOGARAM2 TOMM34 TOP1 TOP2A TOP2B TP53 TP53BP1 TPI1 TPP2 TPT1 TPX2 TRIB2 TRIM25 TRIM33 TRIM4 TRIR TRRAP TSN TSNAX TTC9C TTF2 TTLL12 TUBB4A TUBB4B TUBG1 TUBGCP2 TUBGCP3 TWF2 TXLNA TXLNG TXN TXNDC5 TXNL1 TXNRD1 U2SURP UBA1 UBA2 UBE2I UBE2K UBQLN1 UBR5 UBTF UBXN1 UCHL3 UNG UPF1 UPF3B USP14 USP22 USP39 VARS1 VASP WARS1 WBP11 WDR74 WDR82 WIPF1 WRNIP1 XPO1 XPO5 XPOT XRCC5 XRCC6 XRN2 YBX1 YY1 ZBTB16 ZC3H11A ZC3H15 ZFR ZMAT2 ZNF207 ZRANB2 ZW10 ZYX
Entrez ID		1017	1050
HPRD ID		00310	00296
Ensembl ID		ENSG00000123374	ENSG00000245848
Uniprot IDs		B4DDL9 E7ESI2 G3V5T9 P24941	P49715
PDB IDs		1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H07 1H08 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P2A 1P5E 1PF8 1PKD 1PW2 1PXI 1PXJ 1PXK 1PXL 1PXM 1PXN 1PXO 1PXP 1PYE 1QMZ 1R78 1URC 1URW 1V1K 1VYW 1VYZ 1W0X 1W8C 1W98 1WCC 1Y8Y 1Y91 1YKR 2A0C 2A4L 2B52 2B53 2B54 2B55 2BHE 2BHH 2BKZ 2BPM 2BTR 2BTS 2C4G 2C5N 2C5O 2C5V 2C5X 2C5Y 2C68 2C69 2C6I 2C6K 2C6L 2C6M 2C6O 2C6T 2CCH 2CCI 2CJM 2CLX 2DS1 2DUV 2EXM 2FVD 2G9X 2I40 2IW6 2IW8 2IW9 2J9M 2JGZ 2R3F 2R3G 2R3H 2R3I 2R3J 2R3K 2R3L 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R 2R64 2UUE 2UZB 2UZD 2UZE 2UZL 2UZN 2UZO 2V0D 2V22 2VTA 2VTH 2VTI 2VTJ 2VTL 2VTM 2VTN 2VTO 2VTP 2VTQ 2VTR 2VTS 2VTT 2VU3 2VV9 2W05 2W06 2W17 2W1H 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 2XMY 2XNB 3BHT 3BHU 3BHV 3DDP 3DDQ 3DOG 3EID 3EJ1 3EOC 3EZR 3EZV 3F5X 3FZ1 3IG7 3IGG 3LE6 3LFN 3LFQ 3LFS 3MY5 3NS9 3PJ8 3PXF 3PXQ 3PXR 3PXY 3PXZ 3PY0 3PY1 3QHR 3QHW 3QL8 3QQF 3QQG 3QQH 3QQJ 3QQK 3QQL 3QRT 3QRU 3QTQ 3QTR 3QTS 3QTU 3QTW 3QTX 3QTZ 3QU0 3QWJ 3QWK 3QX2 3QX4 3QXO 3QXP 3QZF 3QZG 3QZH 3QZI 3R1Q 3R1S 3R1Y 3R28 3R6X 3R71 3R73 3R7E 3R7I 3R7U 3R7V 3R7Y 3R83 3R8L 3R8M 3R8P 3R8U 3R8V 3R8Z 3R9D 3R9H 3R9N 3R9O 3RAH 3RAI 3RAK 3RAL 3RJC 3RK5 3RK7 3RK9 3RKB 3RM6 3RM7 3RMF 3RNI 3ROY 3RPO 3RPR 3RPV 3RPY 3RZB 3S00 3S0O 3S1H 3S2P 3SQQ 3SW4 3SW7 3TI1 3TIY 3TIZ 3TNW 3ULI 3UNJ 3UNK 3WBL 4ACM 4BCK 4BCM 4BCN 4BCO 4BCP 4BCQ 4BGH 4BZD 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4D1X 4D1Z 4EK3 4EK4 4EK5 4EK6 4EK8 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4ERW 4EZ3 4EZ7 4FKG 4FKI 4FKJ 4FKL 4FKO 4FKP 4FKQ 4FKR 4FKS 4FKT 4FKU 4FKV 4FKW 4FX3 4GCJ 4I3Z 4II5 4KD1 4LYN 4NJ3 4RJ3 5A14 5AND 5ANE 5ANG 5ANI 5ANJ 5ANK 5ANO 5CYI 5D1J 5FP5 5FP6 5IEV 5IEX 5IEY 5IF1 5JQ5 5JQ8 5K4J 5L2W 5LMK 5MHQ 5NEV 5OO0 5OO1 5OO3 5OSJ 5OSM 5UQ1 5UQ2 5UQ3 6ATH 6GUB 6GUC 6GUE 6GUF 6GUH 6GUK 6GVA 6INL 6JGM 6OQI 6P3W 6Q3B 6Q3C 6Q3F 6Q48 6Q49 6Q4A 6Q4B 6Q4C 6Q4D 6Q4E 6Q4F 6Q4G 6Q4H 6Q4I 6Q4J 6Q4K 6RIJ 6SG4 6YL1 6YL6 6YLK 7ACK 7B5L 7B5R 7B7S 7E34 7KJS 7M2F 7MKX 7NVQ 7QHL 7RA5 7RWE 7RWF 7RXO 7S4T 7S7A 7S84 7S85 7S9X 7SA0 7UG1 7UXI 7UXK 7VDU 7ZPC 8B54 8BYA 8BZO 8CUR 8ERD 8ERN 8FOW 8FP0 8FP5 8H6P 8H6T 8OR0 8OR4 8OY2 8ROZ 8RU8 8UV0 8VQ3 8VQ4 9FR2	6DC0 8K8C
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Cell Cycle Nucleus Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition DNA Damage Response Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Cell Population Proliferation Cell Cycle G1/S Phase Transition Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process DNA Repair DNA Replication Chromatin Nucleobase-containing Compound Metabolic Process Protein Kinase Binding Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Chromatin Remodeling DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity DNA Binding	RNA Binding Nucleoplasm Nucleus Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Cytosol Cytoplasm MRNA Metabolic Process Macromolecule Metabolic Process MRNA Processing RNA Splicing RNA Processing Spliceosomal Complex RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Binding MRNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Organization Catalytic Step 2 Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleotide Binding ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Protein-containing Complex Assembly Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Positive Regulation Of Biosynthetic Process Cadherin Binding Regulation Of DNA Metabolic Process Chromatin Binding Ficolin-1-rich Granule Lumen Nucleolus Regulation Of Gene Expression Cellular Component Assembly Proteasome Complex Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Stress Granule ATP Hydrolysis Activity Positive Regulation Of RNA Biosynthetic Process
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